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LY6K lymphocyte antigen 6 family member K [ Homo sapiens (human) ]

Gene ID: 54742, updated on 5-Mar-2024

Summary

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Official Symbol
LY6Kprovided by HGNC
Official Full Name
lymphocyte antigen 6 family member Kprovided by HGNC
Primary source
HGNC:HGNC:24225
See related
Ensembl:ENSG00000160886 MIM:615093; AllianceGenome:HGNC:24225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT97; ly-6K; URLC10; HSJ001348
Summary
Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to act upstream of or within flagellated sperm motility. Predicted to be located in cell surface; cytoplasm; and plasma membrane. Predicted to be active in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 9.3), fat (RPKM 2.1) and 4 other tissues See more
Orthologs
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Genomic context

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See LY6K in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142700111..142705127)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143843499..143848515)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143781529..143786545)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19603 Neighboring gene prostate stem cell antigen Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143762658-143763304 Neighboring gene uncharacterized LOC124902032 Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19605 Neighboring gene thioesterase superfamily member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143819807-143820373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19607 Neighboring gene secreted LY6/PLAUR domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LY6K depletion modulates TGF-β and EGF signaling. Park S, et al. Cancer Med, 2023 Jun. PMID 37076981, Free PMC Article
  2. LY6K-AS lncRNA is a lung adenocarcinoma prognostic biomarker and regulator of mitotic progression. Ali MM, et al. Oncogene, 2021 Apr. PMID 33674747
  3. LY6K promotes glioblastoma tumorigenicity via CAV-1-mediated ERK1/2 signaling enhancement. Sastry NG, et al. Neuro Oncol, 2020 Sep 29. PMID 32055849, Free PMC Article
  4. Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma. Kong HK, et al. Oncotarget, 2016 Aug 23. PMID 27494879, Free PMC Article
  5. Genome-wide expression and copy number analysis identifies driver genes in gingivobuccal cancers. Ambatipudi S, et al. Genes Chromosomes Cancer, 2012 Feb. PMID 22072328, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LY6K depletion modulates TGF-beta and EGF signaling.
    Title: LY6K depletion modulates TGF-β and EGF signaling.
  2. Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction.
    Title: Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction.
  3. Down-regulation of ZNF252P-AS1 alleviates ovarian cancer progression by binding miR-324-3p to downregulate LY6K.
    Title: Down-regulation of ZNF252P-AS1 alleviates ovarian cancer progression by binding miR-324-3p to downregulate LY6K.
  4. LY6K-AS lncRNA is a lung adenocarcinoma prognostic biomarker and regulator of mitotic progression.
    Title: LY6K-AS lncRNA is a lung adenocarcinoma prognostic biomarker and regulator of mitotic progression.
  5. LY6K promotes glioblastoma tumorigenicity via CAV-1-mediated ERK1/2 signaling enhancement.
    Title: LY6K promotes glioblastoma tumorigenicity via CAV-1-mediated ERK1/2 signaling enhancement.
  6. miR-500a-3p acts as a tumor suppressor in non-small cell lung cancer partially via down-regulation of LY6K expression
    Title: MiRNA-500a-3p inhibits cell proliferation and invasion by targeting lymphocyte antigen 6 complex locus K (LY6K) in human non-small cell lung cancer.
  7. breast cancer risk and metastasis were significantly associated with not only LY6K expression, but also methylation of CGI shore which induced by SNP242 mutation.
    Title: Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma.
  8. miR-192-5p, induced by LY6K, downregulates ERalpha directly and induced tamoxifen resistance in ERalpha-positive breast cancer cells; re-expression of ERalpha in ERalpha-negative breast cancer cells increased miR-500a-3p expression and directly inhibits LY6K expression
    Title: miRNAs involved in LY6K and estrogen receptor α contribute to tamoxifen-susceptibility in breast cancer.
  9. LY6K overexpression is associated with Breast Cancer Progression, Immune Escape, and Drug Resistance.
    Title: Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance.
  10. Data show that TTK protein kinase, lymphocyte antigen 6 complex locus K and insulin-like growth factor (IGF)-II mRNA binding protein 3 are tumor-associated antigens recognized by cytotoxic T lymphocytes and HLA-A24-restricted epitope peptides.
    Title: Identification of human leukocyte antigen-A24-restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35226

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte antigen 6K
Names
cancer/testis antigen 97
lymphocyte antigen 6 complex, locus K
up-regulated in lung cancer 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160354.2 → NP_001153826.1  lymphocyte antigen 6K isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that causes a frameshift, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC001291, BG491223, CB528496
    UniProtKB/Swiss-Prot
    Q17RY6

  2. NM_001160355.2 → NP_001153827.1  lymphocyte antigen 6K isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that causes a frameshift, compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AI740834, BC001291, BG491223
    Consensus CDS
    CCDS59114.1
    UniProtKB/Swiss-Prot
    Q17RY6
    Related
    ENSP00000429695.1, ENST00000519387.1

  3. NM_017527.4 → NP_059997.3  lymphocyte antigen 6K isoform 1 precursor

    See identical proteins and their annotated locations for NP_059997.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC108002, BC001291, BG491223
    Consensus CDS
    CCDS6385.2
    UniProtKB/Swiss-Prot
    G3V116, O15227, Q17RY6, Q9BVD7
    Related
    ENSP00000292430.6, ENST00000292430.10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142700111..142705127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250990.6 → XP_005251047.1  lymphocyte antigen 6K isoform X2

  2. XM_005250989.6 → XP_005251046.1  lymphocyte antigen 6K isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    143843499..143848515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360724.1 → XP_054216699.1  lymphocyte antigen 6K isoform X2

  2. XM_054360723.1 → XP_054216698.1  lymphocyte antigen 6K isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17RY6.2 GenPept UniProtKB/Swiss-Prot:Q17RY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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