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POU6F1 POU class 6 homeobox 1 [ Homo sapiens (human) ]

Gene ID: 5463, updated on 3-Apr-2024

Summary

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Official Symbol
POU6F1provided by HGNC
Official Full Name
POU class 6 homeobox 1provided by HGNC
Primary source
HGNC:HGNC:9224
See related
Ensembl:ENSG00000184271 MIM:618043; AllianceGenome:HGNC:9224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN5; MPOU; TCFB1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 4.7), ovary (RPKM 3.6) and 23 other tissues See more
Orthologs
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Genomic context

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See POU6F1 in Genome Data Viewer
Location:
12q13.13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (51186936..51218062, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (51149818..51180972, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51580719..51611846, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transcription factor CP2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6370 Neighboring gene RNA, U6 small nuclear 199, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51566351-51567098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6371 Neighboring gene uncharacterized LOC124902933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51593597-51594096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6373 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:51614127-51614306 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51631660-51632297 Neighboring gene Sharpr-MPRA regulatory region 9853 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51633573-51634209 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51641233-51641734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51641735-51642234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51642235-51642736 Neighboring gene DAZ associated protein 2 Neighboring gene small cell adhesion glycoprotein Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51663873-51664373 Neighboring gene bridging integrator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6376 Neighboring gene Sharpr-MPRA regulatory region 8177 Neighboring gene uncharacterized LOC105369767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4466

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary. Yoshioka N, et al. Hum Cell, 2009 Nov. PMID 19874398
  2. Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. Pereira JH, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Mar 1. PMID 18323601, Free PMC Article
  3. A novel POU domain protein which binds to the T-cell receptor beta enhancer. Messier H, et al. Mol Cell Biol, 1993 Sep. PMID 8102789, Free PMC Article
  4. Aurora kinase A-mediated phosphorylation of mPOU at a specific site drives skeletal muscle differentiation. Karthigeyan D, et al. J Biochem, 2020 Feb 1. PMID 31665313
  5. Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. Suzuki N, et al. Int J Gynecol Cancer, 2010 Feb. PMID 20134265

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer.
    Title: POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer.
  2. results signify mPOU as a negative regulator of skeletal muscle differentiation and strengthen the importance of AurkA in skeletal myogenesis
    Title: Aurora kinase A-mediated phosphorylation of mPOU at a specific site drives skeletal muscle differentiation.
  3. POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines.
    Title: Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target.
  4. is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary.
    Title: POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary.
  5. The crystal structure of human Brn-5 transcription factor in complex with corticotropin-releasing hormone gene promoter reveals an unexpected recognition mode of the protein to its cognate DNA
    Title: Structure of human Brn-5 transcription factor in complex with CRH gene promoter.
  6. Crystallization and preliminary X-ray analysis
    Title: Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of POU class 6 homeobox 1 (POU6F1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development TAS
Traceable Author Statement
more info
 PubMed 
involved_in heart development TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle organ development TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
POU domain, class 6, transcription factor 1
Names
brain-5
brain-specific homeobox/POU domain protein 5
mPOU homeobox protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330422.2 → NP_001317351.1  POU domain, class 6, transcription factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC139768
    Consensus CDS
    CCDS81691.1
    UniProtKB/TrEMBL
    A0A1C7CYV8, A0A1C7CYY7
    Related
    ENSP00000330190.11, ENST00000333640.12

  2. NM_001351088.2 → NP_001338017.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 12, encodes isoform 3.
    Source sequence(s)
    AC139768

  3. NM_001368008.1 → NP_001354937.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 4, encodes isoform 3.
    Source sequence(s)
    AC139768

RNA

  1. NR_026893.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139768
    Related
    ENST00000636728.1

  2. NR_147046.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

  3. NR_147047.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

  4. NR_147048.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

  5. NR_147049.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

  6. NR_147050.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

  7. NR_147051.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

  8. NR_147052.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

  9. NR_160429.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

  10. NR_160430.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    51186936..51218062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429037.1 → XP_047284993.1  POU domain, class 6, transcription factor 1 isoform X3

  2. XM_047429034.1 → XP_047284990.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYV8

  3. XM_047429040.1 → XP_047284996.1  POU domain, class 6, transcription factor 1 isoform X6

  4. XM_047429041.1 → XP_047284997.1  POU domain, class 6, transcription factor 1 isoform X7

  5. XM_047429039.1 → XP_047284995.1  POU domain, class 6, transcription factor 1 isoform X5

  6. XM_047429038.1 → XP_047284994.1  POU domain, class 6, transcription factor 1 isoform X4

  7. XM_047429036.1 → XP_047284992.1  POU domain, class 6, transcription factor 1 isoform X2

  8. XM_047429033.1 → XP_047284989.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYV8

  9. XM_017019514.1 → XP_016875003.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYV8, A0A1C7CYY7

  10. XM_047429035.1 → XP_047284991.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYV8

  11. XM_047429043.1 → XP_047284999.1  POU domain, class 6, transcription factor 1 isoform X9

    UniProtKB/Swiss-Prot
    Q14863, Q15944, Q6DK47, Q7Z7P6

  12. XM_047429042.1 → XP_047284998.1  POU domain, class 6, transcription factor 1 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    51149818..51180972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372356.1 → XP_054228331.1  POU domain, class 6, transcription factor 1 isoform X3

  2. XM_054372353.1 → XP_054228328.1  POU domain, class 6, transcription factor 1 isoform X1

  3. XM_054372360.1 → XP_054228335.1  POU domain, class 6, transcription factor 1 isoform X7

  4. XM_054372359.1 → XP_054228334.1  POU domain, class 6, transcription factor 1 isoform X6

  5. XM_054372358.1 → XP_054228333.1  POU domain, class 6, transcription factor 1 isoform X5

  6. XM_054372355.1 → XP_054228330.1  POU domain, class 6, transcription factor 1 isoform X2

  7. XM_054372357.1 → XP_054228332.1  POU domain, class 6, transcription factor 1 isoform X4

  8. XM_054372352.1 → XP_054228327.1  POU domain, class 6, transcription factor 1 isoform X1

  9. XM_054372351.1 → XP_054228326.1  POU domain, class 6, transcription factor 1 isoform X1

  10. XM_054372354.1 → XP_054228329.1  POU domain, class 6, transcription factor 1 isoform X1

  11. XM_054372350.1 → XP_054228325.1  POU domain, class 6, transcription factor 1 isoform X1

  12. XM_054372362.1 → XP_054228337.1  POU domain, class 6, transcription factor 1 isoform X9

    UniProtKB/Swiss-Prot
    Q14863, Q15944, Q6DK47, Q7Z7P6

  13. XM_054372361.1 → XP_054228336.1  POU domain, class 6, transcription factor 1 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002702.3: Suppressed sequence

    Description
    NM_002702.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14863.1 GenPept UniProtKB/Swiss-Prot:Q14863

Gene LinkOut

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