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CCNJ cyclin J [ Homo sapiens (human) ]

Gene ID: 54619, updated on 3-Apr-2024

Summary

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Official Symbol
CCNJprovided by HGNC
Official Full Name
cyclin Jprovided by HGNC
Primary source
HGNC:HGNC:23434
See related
Ensembl:ENSG00000107443 MIM:620395; AllianceGenome:HGNC:23434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA690P14.1
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 3.4), testis (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q24.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (96043068..96060870)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (96922365..96940179)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (97803340..97820627)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:97454143-97454644 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 1 Neighboring gene MPRA-validated peak1056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2650 Neighboring gene ENTPD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3811 Neighboring gene Sharpr-MPRA regulatory region 13404 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:97645298-97645457 Neighboring gene MPRA-validated peak1059 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3814 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene ribosomal protein L21 pseudogene 90 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:97786197-97787396 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:97802729-97802923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3816 Neighboring gene microRNA 3157 Neighboring gene RNA, U6 small nuclear 271, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma. Takano N, et al. Int J Oncol, 2015 May. PMID 25672416
  2. Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J. Shi L, et al. BMC Cancer, 2017 Feb 15. PMID 28202053, Free PMC Article
  3. Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer. Sun X, et al. Cell Death Dis, 2015 Oct 15. PMID 26469956, Free PMC Article
  4. MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. Venturutti L, et al. Oncogene, 2016 Dec 1. PMID 27157613, Free PMC Article
  5. miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9. Feliciano A, et al. PLoS One, 2013. PMID 24098452, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High Cyclin J expression is associated with drug resistance in non-small cell lung cancer.
    Title: Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J.
  2. we identified cyclin J and far upstream element-binding protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16 antiproliferative effects.
    Title: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1.
  3. CCNJ is a target of miR205 mediated downregulation in bladder cancer cells.
    Title: Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer.
  4. In conclusion, our results indicated that CCNJ could be a novel prognostic marker of HCC, and this study indicated that triple combination array analysis was effective in detecting new tumor-related genes and their mechanisms.
    Title: CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma.
  5. miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9.
    Title: miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-J

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134375.2 → NP_001127847.1  cyclin-J isoform 1

    See identical proteins and their annotated locations for NP_001127847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK001757, AK025932, BC043175, BM789816
    Consensus CDS
    CCDS44462.1
    UniProtKB/TrEMBL
    B3KRX5
    Related
    ENSP00000435373.2, ENST00000465148.3
    Conserved Domains (2) summary
    pfam00134
    Location:15 → 109
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:145 → 251
    Cyclin_C; Cyclin, C-terminal domain

  2. NM_001134376.2 → NP_001127848.1  cyclin-J isoform 3

    See identical proteins and their annotated locations for NP_001127848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 3) that lacks twelve internal amino acids, when compared to isoform 1.
    Source sequence(s)
    AK001757, AK025932, BC043175
    Consensus CDS
    CCDS44463.1
    UniProtKB/TrEMBL
    B3KRX5
    Related
    ENSP00000384498.2, ENST00000403870.7
    Conserved Domains (2) summary
    pfam00134
    Location:15 → 109
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:145 → 239
    Cyclin_C; Cyclin, C-terminal domain

  3. NM_019084.5 → NP_061957.2  cyclin-J isoform 2

    See identical proteins and their annotated locations for NP_061957.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 2) that lacks eleven internal amino acids, when compared to isoform 1.
    Source sequence(s)
    AK001757, AK025932, BC043175
    Consensus CDS
    CCDS7445.1
    UniProtKB/Swiss-Prot
    B7Z4E7, Q5T5M9, Q86XL1, Q9NV69
    UniProtKB/TrEMBL
    B3KRX5
    Related
    ENSP00000265992.5, ENST00000265992.9
    Conserved Domains (2) summary
    pfam00134
    Location:15 → 109
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:145 → 240
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    96043068..96060870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539885.3 → XP_011538187.1  cyclin-J isoform X4

    See identical proteins and their annotated locations for XP_011538187.1

    UniProtKB/TrEMBL
    B3KRX5
    Conserved Domains (2) summary
    pfam00134
    Location:15 → 109
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:145 → 251
    Cyclin_C; Cyclin, C-terminal domain

  2. XM_017016354.2 → XP_016871843.1  cyclin-J isoform X1

    UniProtKB/TrEMBL
    B3KRX5
    Conserved Domains (1) summary
    cl40454
    Location:58 → 332
    CYCLIN_SF; Cyclin box fold superfamily

  3. XM_017016356.2 → XP_016871845.1  cyclin-J isoform X3

    UniProtKB/TrEMBL
    B3KRX5

  4. XM_017016355.2 → XP_016871844.2  cyclin-J isoform X2

    UniProtKB/Swiss-Prot
    B7Z4E7, Q5T5M9, Q86XL1, Q9NV69

  5. XM_005269921.4 → XP_005269978.1  cyclin-J isoform X5

    Conserved Domains (1) summary
    pfam02984
    Location:31 → 137
    Cyclin_C; Cyclin, C-terminal domain

  6. XM_047425381.1 → XP_047281337.1  cyclin-J isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    96922365..96940179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366144.1 → XP_054222119.1  cyclin-J isoform X4

  2. XM_054366141.1 → XP_054222116.1  cyclin-J isoform X1

  3. XM_054366142.1 → XP_054222117.1  cyclin-J isoform X7

  4. XM_054366143.1 → XP_054222118.1  cyclin-J isoform X3

  5. XM_054366145.1 → XP_054222120.1  cyclin-J isoform X5

  6. XM_054366146.1 → XP_054222121.1  cyclin-J isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T5M9.2 GenPept UniProtKB/Swiss-Prot:Q5T5M9

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