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St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ Mus musculus (house mouse) ]

Gene ID: 54613, updated on 12-Nov-2024

Summary

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Official Symbol
St3gal6provided by MGI
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 6provided by MGI
Primary source
MGI:MGI:1888707
See related
Ensembl:ENSMUSG00000022747 AllianceGenome:MGI:1888707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat10; St3galVI; 1700023B24Rik
Summary
Predicted to enable N-acetyllactosaminide alpha-2,3-sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in cellular response to interleukin-6; glycolipid biosynthetic process; and protein glycosylation. Predicted to be located in Golgi membrane. Is expressed in dentate gyrus subgranular zone and early tubule. Orthologous to human ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 4.2), lung adult (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See St3gal6 in Genome Data Viewer
Location:
16 C1.2; 16 34.58 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58290105..58344614, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58469742..58524260, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41463 Neighboring gene STARR-seq mESC enhancer starr_41094 Neighboring gene STARR-seq mESC enhancer starr_41095 Neighboring gene RIKEN cDNA 4930461C15 gene Neighboring gene STARR-positive B cell enhancer ABC_E1928 Neighboring gene STARR-seq mESC enhancer starr_41096 Neighboring gene discoidin, CUB and LCCL domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3167 Neighboring gene STARR-positive B cell enhancer ABC_E8639 Neighboring gene STARR-positive B cell enhancer ABC_E3168 Neighboring gene STARR-seq mESC enhancer starr_41097 Neighboring gene predicted gene, 20942 Neighboring gene STARR-seq mESC enhancer starr_41098 Neighboring gene ferritin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy. Li X, et al. J Zhejiang Univ Sci B, 2024 May 15. PMID 38910494, Free PMC Article
  2. Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. Yang WH, et al. Blood, 2012 Aug 2. PMID 22700726, Free PMC Article
  3. Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase. Kapitonov D, et al. Glycoconj J, 1999 Jul. PMID 10619706
  4. Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis. Yang WH, et al. iScience, 2023 Oct 20. PMID 37752945, Free PMC Article
  5. Comparison of genomic structures of four members of beta-galactoside alpha2,3-sialyltransferase genes in the mouse. Takashima S, et al. Cytogenet Cell Genet, 2000. PMID 10894948

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sialyltransferase ST3GAL6 silencing reduces alpha2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy.
    Title: Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy.
  2. Coordinated participation of both ST3Gal-VI and ST3Gal-IV in the synthesis of functional selectin ligands.
    Title: Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to interleukin-6 ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type 2 lactosamine alpha-2,3-sialyltransferase
Names
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
ST3Gal VI
alpha-2,3-sialyltransferase VI
sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
NP_001344362.1
NP_001344363.1
NP_001344364.1
NP_001390061.1
NP_001390062.1
NP_001390063.1
NP_001390064.1
NP_001390065.1
NP_001390066.1
NP_061254.1
XP_011244276.1
XP_011244277.1
XP_011244278.1
XP_030105054.1
XP_036015919.1
XP_036015920.1
XP_036015921.1
XP_036015922.1
XP_036015923.1
XP_036015924.1
XP_036015925.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357433.2 → NP_001344362.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    Consensus CDS
    CCDS28230.1
    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
    Related
    ENSMUSP00000109998.3, ENSMUST00000114358.9
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001357434.2 → NP_001344363.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    Conserved Domains (1) summary
    pfam00777
    Location:69 → 318
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. NM_001357435.2 → NP_001344364.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    Consensus CDS
    CCDS28230.1
    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
    Related
    ENSMUSP00000109997.4, ENSMUST00000114357.10
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. NM_001403132.1 → NP_001390061.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2

  5. NM_001403133.1 → NP_001390062.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2

  6. NM_001403134.1 → NP_001390063.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2

  7. NM_001403135.1 → NP_001390064.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT027564
    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2

  8. NM_001403136.1 → NP_001390065.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

  9. NM_001403137.1 → NP_001390066.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT027564

  10. NM_018784.3 → NP_061254.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    See identical proteins and their annotated locations for NP_061254.1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    Consensus CDS
    CCDS28230.1
    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
    Related
    ENSMUSP00000115756.2, ENSMUST00000137035.8
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_175353.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

  2. NR_175354.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

  3. NR_175355.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

  4. NR_175356.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    58290105..58344614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245975.3 → XP_011244277.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:69 → 318
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_036160029.1 → XP_036015922.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_036160028.1 → XP_036015921.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_036160030.1 → XP_036015923.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_036160026.1 → XP_036015919.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:129 → 378
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. XM_030249194.1 → XP_030105054.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X7

    Conserved Domains (1) summary
    pfam00777
    Location:5 → 254
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_036160032.1 → XP_036015925.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  8. XM_011245974.4 → XP_011244276.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    See identical proteins and their annotated locations for XP_011244276.1

    UniProtKB/Swiss-Prot
    Q3TRN3, Q80UR7, Q8VIB3, Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  9. XM_036160031.1 → XP_036015924.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X6

    Conserved Domains (1) summary
    pfam00777
    Location:79 → 303
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  10. XM_011245976.4 → XP_011244278.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X6

    Conserved Domains (1) summary
    pfam00777
    Location:79 → 303
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  11. XM_036160027.1 → XP_036015920.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:139 → 363
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_384577.5 RNA Sequence

  2. XR_003951805.2 RNA Sequence

  3. XR_003951802.2 RNA Sequence

  4. XR_004939201.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VIB3.3 GenPept UniProtKB/Swiss-Prot:Q8VIB3

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