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MIER2 MIER family member 2 [ Homo sapiens (human) ]

Gene ID: 54531, updated on 5-Mar-2024

Summary

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Official Symbol
MIER2provided by HGNC
Official Full Name
MIER family member 2provided by HGNC
Primary source
HGNC:HGNC:29210
See related
Ensembl:ENSG00000105556 MIM:620092; AllianceGenome:HGNC:29210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mi-er2; KIAA1193
Summary
Enables histone deacetylase binding activity. Contributes to histone deacetylase activity. Involved in histone deacetylation. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 6.0), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (305573..344796, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (255525..294230, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (305573..344796, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:281525-282216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:282217-282907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:287125-287626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:287627-288126 Neighboring gene hESC enhancers GRCh37_chr19:289901-290599 and GRCh37_chr19:290600-291297 Neighboring gene phospholipid phosphatase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:293997-294846 Neighboring gene uncharacterized LOC124904605 Neighboring gene MPRA-validated peak3203 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:327661-328161 Neighboring gene MPRA-validated peak3205 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:341127-341714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:342901-343852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9599 Neighboring gene MPRA-validated peak3207 silencer Neighboring gene MPRA-validated peak3208 silencer Neighboring gene sperm microtubule associated protein 2 Neighboring gene uncharacterized LOC124904606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13554 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:383808-384334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:384335-384861 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:386621-387186

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
  2. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Lee Y, et al. Carcinogenesis, 2013 Feb. PMID 23144319
  3. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Bantscheff M, et al. Nat Biotechnol, 2011 Mar. PMID 21258344
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462
  5. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Tang W, et al. Nat Commun, 2019 Feb 8. PMID 30737378, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mesoderm induction early response protein 2
Names
mesoderm induction early response 1, family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346105.2 → NP_001333034.1  mesoderm induction early response protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:266 → 310
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:161 → 211
    ELM2; ELM2 domain

  2. NM_001387152.1 → NP_001374081.1  mesoderm induction early response protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199 → 249
    ELM2; ELM2 domain

  3. NM_001387153.1 → NP_001374082.1  mesoderm induction early response protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (3) summary
    cd11661
    Location:302 → 346
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    TIGR01649
    Location:353 → 457
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    pfam01448
    Location:197 → 247
    ELM2; ELM2 domain

  4. NM_001387154.1 → NP_001374083.1  mesoderm induction early response protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (3) summary
    cd11661
    Location:266 → 310
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    TIGR01649
    Location:317 → 421
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    pfam01448
    Location:161 → 211
    ELM2; ELM2 domain

  5. NM_001387155.1 → NP_001374084.1  mesoderm induction early response protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:266 → 310
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:161 → 211
    ELM2; ELM2 domain

  6. NM_001387156.1 → NP_001374085.1  mesoderm induction early response protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:218 → 262
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:113 → 163
    ELM2; ELM2 domain

  7. NM_001387157.1 → NP_001374086.1  mesoderm induction early response protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016588
    Conserved Domains (2) summary
    cd11661
    Location:218 → 262
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:113 → 163
    ELM2; ELM2 domain

  8. NM_017550.3 → NP_060020.1  mesoderm induction early response protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC016588
    Consensus CDS
    CCDS32855.1
    UniProtKB/Swiss-Prot
    Q8N344, Q9ULM7
    Related
    ENSP00000264819.3, ENST00000264819.7
    Conserved Domains (3) summary
    smart00717
    Location:301 → 347
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:302 → 346
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:197 → 247
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    305573..344796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438972.1 → XP_047294928.1  mesoderm induction early response protein 2 isoform X5

  2. XM_047438970.1 → XP_047294926.1  mesoderm induction early response protein 2 isoform X2

  3. XM_047438978.1 → XP_047294934.1  mesoderm induction early response protein 2 isoform X5

  4. XM_006722769.5 → XP_006722832.1  mesoderm induction early response protein 2 isoform X4

    Conserved Domains (3) summary
    smart00717
    Location:303 → 349
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199 → 249
    ELM2; ELM2 domain

  5. XM_047438971.1 → XP_047294927.1  mesoderm induction early response protein 2 isoform X3

  6. XM_047438969.1 → XP_047294925.1  mesoderm induction early response protein 2 isoform X1

  7. XM_047438977.1 → XP_047294933.1  mesoderm induction early response protein 2 isoform X5

  8. XM_047438976.1 → XP_047294932.1  mesoderm induction early response protein 2 isoform X5

  9. XM_047438975.1 → XP_047294931.1  mesoderm induction early response protein 2 isoform X5

  10. XM_047438974.1 → XP_047294930.1  mesoderm induction early response protein 2 isoform X5

  11. XM_047438973.1 → XP_047294929.1  mesoderm induction early response protein 2 isoform X5

  12. XM_047438979.1 → XP_047294935.1  mesoderm induction early response protein 2 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    255525..294230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321266.1 → XP_054177241.1  mesoderm induction early response protein 2 isoform X4

  2. XM_054321267.1 → XP_054177242.1  mesoderm induction early response protein 2 isoform X5

  3. XM_054321264.1 → XP_054177239.1  mesoderm induction early response protein 2 isoform X2

  4. XM_054321272.1 → XP_054177247.1  mesoderm induction early response protein 2 isoform X5

  5. XM_054321265.1 → XP_054177240.1  mesoderm induction early response protein 2 isoform X3

  6. XM_054321263.1 → XP_054177238.1  mesoderm induction early response protein 2 isoform X1

  7. XM_054321271.1 → XP_054177246.1  mesoderm induction early response protein 2 isoform X5

  8. XM_054321270.1 → XP_054177245.1  mesoderm induction early response protein 2 isoform X5

  9. XM_054321269.1 → XP_054177244.1  mesoderm induction early response protein 2 isoform X5

  10. XM_054321268.1 → XP_054177243.1  mesoderm induction early response protein 2 isoform X5

  11. XM_054321273.1 → XP_054177248.1  mesoderm induction early response protein 2 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N344.2 GenPept UniProtKB/Swiss-Prot:Q8N344

Gene LinkOut

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