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ARMCX6 armadillo repeat containing X-linked 6 [ Homo sapiens (human) ]

Gene ID: 54470, updated on 2-Nov-2024

Summary

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Official Symbol
ARMCX6provided by HGNC
Official Full Name
armadillo repeat containing X-linked 6provided by HGNC
Primary source
HGNC:HGNC:26094
See related
Ensembl:ENSG00000198960 MIM:301048; AllianceGenome:HGNC:26094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASP10
Summary
Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen (RPKM 13.9), endometrium (RPKM 12.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ARMCX6 in Genome Data Viewer
Location:
Xq22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101615125..101618000, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (100059755..100062630, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100870115..100872990, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing X-linked 1 Neighboring gene armadillo repeat containing X-linked 7, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:100868599-100869161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29812 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:100878731-100879930 Neighboring gene armadillo repeat containing X-linked 3 Neighboring gene RNA, U6 small nuclear 30, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer's Disease. Zhang X, et al. J Alzheimers Dis, 2024. PMID 38489177
  2. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
  4. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article
  5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer's Disease.
    Title: An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer's Disease.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20811

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein ARMCX6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021313.2 RefSeqGene

    Range
    5000..7875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009584.2 → NP_001009584.1  protein ARMCX6

    See identical proteins and their annotated locations for NP_001009584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI076820, BC007677
    Consensus CDS
    CCDS14488.1
    UniProtKB/Swiss-Prot
    Q7L4S7, Q9NWJ3
    Related
    ENSP00000440648.1, ENST00000538627.5
    Conserved Domains (1) summary
    pfam04826
    Location:123 → 295
    Arm_2; Armadillo-like

  2. NM_001184768.2 → NP_001171697.1  protein ARMCX6

    See identical proteins and their annotated locations for NP_001171697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    BC007677, DA933518
    Consensus CDS
    CCDS14488.1
    UniProtKB/Swiss-Prot
    Q7L4S7, Q9NWJ3
    Related
    ENSP00000444537.1, ENST00000539247.5
    Conserved Domains (1) summary
    pfam04826
    Location:123 → 295
    Arm_2; Armadillo-like

  3. NM_019007.4 → NP_061880.2  protein ARMCX6

    See identical proteins and their annotated locations for NP_061880.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI076820, BC007677
    Consensus CDS
    CCDS14488.1
    UniProtKB/Swiss-Prot
    Q7L4S7, Q9NWJ3
    Related
    ENSP00000354708.4, ENST00000361910.9
    Conserved Domains (1) summary
    pfam04826
    Location:123 → 295
    Arm_2; Armadillo-like

RNA

  1. NR_033669.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks most of the coding region compared to variant 1. This variant is not thought to be protein-coding.
    Source sequence(s)
    AI076820, BX423052
    Related
    ENST00000497931.5

  2. NR_033670.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks most of the coding region compared to variant 1. This variant is not thought to be protein-coding.
    Source sequence(s)
    AI076820, AW955663, BC007677, BX423052

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    101615125..101618000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530976.3 → XP_011529278.1  protein ARMCX6 isoform X1

    Conserved Domains (1) summary
    pfam04826
    Location:186 → 358
    Arm_2; Armadillo-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    100059755..100062630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327272.1 → XP_054183247.1  protein ARMCX6 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L4S7.1 GenPept UniProtKB/Swiss-Prot:Q7L4S7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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