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RBM27 RNA binding motif protein 27 [ Homo sapiens (human) ]

Gene ID: 54439, updated on 7-Apr-2024

Summary

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Official Symbol
RBM27provided by HGNC
Official Full Name
RNA binding motif protein 27provided by HGNC
Primary source
HGNC:HGNC:29243
See related
Ensembl:ENSG00000091009 MIM:620082; AllianceGenome:HGNC:29243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Psc1; ARRS1; ZC3H18; ZC3H20
Summary
Enables RNA binding activity. Predicted to be involved in mRNA processing. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 10.3), bone marrow (RPKM 8.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See RBM27 in Genome Data Viewer
Location:
5q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (146203605..146289223)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (146739205..146824811)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145583168..145668786)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene leucyl-tRNA synthetase 1 Neighboring gene ribosomal protein L35a pseudogene 16 Neighboring gene ribosomal protein L35a pseudogene 17 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81447 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81571 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81576 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81597 Neighboring gene MPRA-validated peak5520 silencer Neighboring gene MPRA-validated peak5521 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145562805-145563651 Neighboring gene Sharpr-MPRA regulatory region 14811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23360 Neighboring gene RBM27-POU4F3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23361 Neighboring gene Sharpr-MPRA regulatory region 15600 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81701 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81715 Neighboring gene RNA, U7 small nuclear 180 pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81725 Neighboring gene MPRA-validated peak5522 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:145724002-145724515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145725029-145725541 Neighboring gene POU class 4 homeobox 3 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81810 Neighboring gene uncharacterized LOC105378213

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay. Silla T, et al. Nucleic Acids Res, 2020 Mar 18. PMID 31950173, Free PMC Article
  2. A family of RS domain proteins with novel subcellular localization and trafficking. Kavanagh SJ, et al. Nucleic Acids Res, 2005. PMID 15741184, Free PMC Article
  3. Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex. Roboti P, et al. J Cell Sci, 2022 May 1. PMID 35543156, Free PMC Article
  4. An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry. Hecht M, et al. G3 (Bethesda), 2019 Jun 5. PMID 30975701, Free PMC Article
  5. Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific. Zouboulis CC, et al. J Eur Acad Dermatol Venereol, 2020 Jul. PMID 32031713

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAPgamma associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs.
    Title: PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs.
  2. three additional proteins required for Poly(A) Tail eXosome Targeting (PAXT) function: ZC3H3, RBM26 and RBM27 along with the known PAXT-associated protein, PABPN1, were identified.
    Title: The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough LOC127814297

Readthrough gene: LOC127814297, Included gene: POU4F3

Homology

Clone Names

  • KIAA1311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 27
Names
acidic rich RS domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018989.2 → NP_061862.1  RNA-binding protein 27

    See identical proteins and their annotated locations for NP_061862.1

    Status: VALIDATED

    Source sequence(s)
    AB037732, AL833706, BX647384
    Consensus CDS
    CCDS43378.1
    UniProtKB/Swiss-Prot
    Q8IYW9, Q9P2N5
    UniProtKB/TrEMBL
    U3KPZ7
    Related
    ENSP00000265271.5, ENST00000265271.7
    Conserved Domains (5) summary
    cd12517
    Location:599 → 674
    RRM_RBM27; RNA recognition motif of vertebrate RNA-binding protein 27 (RBM27)
    pfam00642
    Location:277 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl02562
    Location:7 → 72
    PWI; PWI domain
    cl17169
    Location:971 → 1013
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl19219
    Location:813 → 902
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    146203605..146289223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    146739205..146824811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2N5.2 GenPept UniProtKB/Swiss-Prot:Q9P2N5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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