Zfp326 zinc finger protein 326 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp326provided by MGI
Official Full Name: zinc finger protein 326provided by MGI
Primary source: MGI:MGI:1927246
See related: Ensembl:ENSMUSG00000029290 AllianceGenome:MGI:1927246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZAN75; Znf326; 5730470H14Rik
Summary: Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nuclear matrix. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human ZNF326 (zinc finger protein 326). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 13.2), CNS E14 (RPKM 9.1) and 25 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 E5; 5 50.88 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (106024422..106063684)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (105876556..105915818)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

involvement of the Zfp326 and ZNF326 genes in antidepressant treatment response
Title: Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Transposon induced (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II complex binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of DBIRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DBIRD complex	ISO Inferred from Sequence Orthology more info
part_of DBIRD complex	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: DBIRD complex subunit ZNF326

Names: zinc finger protein interacting with mRNPs; zinc finger protein-associated with nuclear matrix of 75 kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018759.2 → NP_061229.2 DBIRD complex subunit ZNF326

See identical proteins and their annotated locations for NP_061229.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes a zinc finger protein.

Source sequence(s)

AK017693, AV503563, DR754281

Consensus CDS

CCDS19496.1

UniProtKB/Swiss-Prot

O88291, Q05DP5, Q3TRI9, Q3UJI3, Q8BSJ5, Q8K1X9, Q9CYG9

UniProtKB/TrEMBL

A0A0R4J098

Related

ENSMUSP00000031227.5, ENSMUST00000031227.11

Conserved Domains (1) summary

pfam04988
Location:337 → 472

AKAP95; A-kinase anchoring protein 95 (AKAP95)

RNA

NR_030777.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) has alternate splice sites in the 5' coding region, as compared to variant 1. The resulting transcript is a nonsense-mediated mRNA decay (NMD) candidate, so is probably not making a protein.

Source sequence(s)

AK017693, AV503563, BU503985, DR754281

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

106024422..106063684

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535131.4 → XP_006535194.1 DBIRD complex subunit ZNF326 isoform X2

See identical proteins and their annotated locations for XP_006535194.1

Conserved Domains (1) summary

pfam04988
Location:131 → 266

AKAP95; A-kinase anchoring protein 95 (AKAP95)
XM_036165311.1 → XP_036021204.1 DBIRD complex subunit ZNF326 isoform X2

Conserved Domains (1) summary

pfam04988
Location:131 → 266

AKAP95; A-kinase anchoring protein 95 (AKAP95)
XM_030254703.2 → XP_030110563.1 DBIRD complex subunit ZNF326 isoform X2

Conserved Domains (1) summary

pfam04988
Location:131 → 266

AKAP95; A-kinase anchoring protein 95 (AKAP95)
XM_036165312.1 → XP_036021205.1 DBIRD complex subunit ZNF326 isoform X2

Conserved Domains (1) summary

pfam04988
Location:131 → 266

AKAP95; A-kinase anchoring protein 95 (AKAP95)
XM_006535128.5 → XP_006535191.1 DBIRD complex subunit ZNF326 isoform X1

See identical proteins and their annotated locations for XP_006535191.1

UniProtKB/Swiss-Prot

O88291, Q05DP5, Q3TRI9, Q3UJI3, Q8BSJ5, Q8K1X9, Q9CYG9

Conserved Domains (1) summary

pfam04988
Location:291 → 456

AKAP95; A-kinase anchoring protein 95 (AKAP95)