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Rgs6 regulator of G-protein signaling 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54295, updated on 2-Nov-2024

Summary

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Official Symbol
Rgs6provided by RGD
Official Full Name
regulator of G-protein signaling 6provided by RGD
Primary source
RGD:3569
See related
EnsemblRapid:ENSRNOG00000008082 AllianceGenome:RGD:3569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein domain specific binding activity. Involved in positive regulation of neuron differentiation. Part of protein-containing complex. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS6 (regulator of G protein signaling 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 93.2), Lung (RPKM 52.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rgs6 in Genome Data Viewer
Location:
6q24-q31
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (107875883..108527472)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (102264451..102796311)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (106310442..106598668)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation-associated 1 like 1 Neighboring gene uncharacterized LOC134479448 Neighboring gene uncharacterized LOC102552965 Neighboring gene uncharacterized LOC134479449 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479450 Neighboring gene polyadenylate-binding protein 1-like Neighboring gene uncharacterized LOC120093216 Neighboring gene uncharacterized LOC120093217 Neighboring gene double PHD fingers 3 Neighboring gene uncharacterized LOC134479225 Neighboring gene uncharacterized LOC134479227 Neighboring gene DDB1 and CUL4 associated factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, et al. Front Physiol, 2012. PMID 22685433, Free PMC Article
  2. RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6. Liu Z, et al. J Biol Chem, 2002 Oct 4. PMID 12140291
  3. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. Posner BA, et al. J Biol Chem, 1999 Oct 22. PMID 10521509
  4. Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. Gold SJ, et al. J Neurosci, 1997 Oct 15. PMID 9315921, Free PMC Article
  5. An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. Chen G, et al. Addict Biol, 2017 Nov. PMID 27151647

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019342.1 → NP_062215.1  regulator of G-protein signaling 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6GJP9, F1LS67
    Related
    ENSRNOP00000054984.6, ENSRNOT00000058181.6
    Conserved Domains (3) summary
    smart00224
    Location:258 → 319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328 → 452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31 → 119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    107875883..108527472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262367.1 → XP_063118437.1  regulator of G-protein signaling 6 isoform X1

  2. XM_063262368.1 → XP_063118438.1  regulator of G-protein signaling 6 isoform X4

    Related
    ENSRNOP00000091512.2, ENSRNOT00000113156.2

  3. XM_063262369.1 → XP_063118439.1  regulator of G-protein signaling 6 isoform X5

  4. XM_039112789.2 → XP_038968717.2  regulator of G-protein signaling 6 isoform X6

  5. XM_039112787.2 → XP_038968715.2  regulator of G-protein signaling 6 isoform X3

    Related
    ENSRNOP00000091378.2, ENSRNOT00000107970.2

  6. XM_039112790.2 → XP_038968718.2  regulator of G-protein signaling 6 isoform X7

    Related
    ENSRNOP00000085795.2, ENSRNOT00000114544.2

  7. XM_039112785.2 → XP_038968713.1  regulator of G-protein signaling 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G3X7, A0A8I6GJP9
    Related
    ENSRNOP00000069089.3, ENSRNOT00000086136.3
    Conserved Domains (4) summary
    smart00224
    Location:258 → 319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328 → 452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31 → 119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:116 → 217
    RGS_DHEX; Regulator of G-protein signalling DHEX domain

  8. XM_063262370.1 → XP_063118440.1  regulator of G-protein signaling 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G3X7

  9. XM_039112783.2 → XP_038968711.1  regulator of G-protein signaling 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G3X7, A0A8I6GJP9
    Related
    ENSRNOP00000079945.1, ENSRNOT00000109319.2
    Conserved Domains (4) summary
    smart00224
    Location:258 → 319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328 → 452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31 → 119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:116 → 217
    RGS_DHEX; Regulator of G-protein signalling DHEX domain

  10. XM_039112784.2 → XP_038968712.1  regulator of G-protein signaling 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G3X7, A0A8I6GJP9
    Conserved Domains (4) summary
    smart00224
    Location:258 → 319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328 → 452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31 → 119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:116 → 217
    RGS_DHEX; Regulator of G-protein signalling DHEX domain

RNA

  1. XR_005505572.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49801.1 GenPept UniProtKB/Swiss-Prot:P49801

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