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Prkg1 protein kinase cGMP-dependent 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54286, updated on 2-Nov-2024

Summary

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Symbol
Prkg1provided by RGD
Full Name
protein kinase cGMP-dependent 1provided by RGD
Primary source
RGD:1587390
See related
EnsemblRapid:ENSRNOG00000053728 AllianceGenome:RGD:1587390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pkgi; cGk1
Summary
Enables identical protein binding activity and mitogen-activated protein kinase p38 binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; negative regulation of inositol phosphate biosynthetic process; and positive regulation of large conductance calcium-activated potassium channel activity. Located in acrosomal vesicle; nucleoplasm; and sarcolemma. Biomarker of allergic rhinitis; hypertension; hypogonadism; impotence; and obesity. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 103.4), Heart (RPKM 98.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prkg1 in Genome Data Viewer
Location:
1q52
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (237818950..239052184, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (228409605..229638794, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (248982039..250300952, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484920 Neighboring gene dickkopf WNT signaling pathway inhibitor 1 Neighboring gene uncharacterized LOC134483987 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene cleavage stimulation factor subunit 2, tau variant Neighboring gene uncharacterized LOC120097462 Neighboring gene uncharacterized LOC120097454 Neighboring gene APOBEC1 complementation factor Neighboring gene N-acylsphingosine amidohydrolase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway. Zhou Y, et al. Cardiovasc Res, 2009 Oct 1. PMID 19542178, Free PMC Article
  2. Restoring nitric oxide cytosolic calcium regulation by cyclic guanosine monophosphate protein kinase I alpha transfection in coronary endothelial cells of spontaneously hypertensive rats. Nistri S, et al. J Vasc Res, 2012. PMID 22433666
  3. Transient rise of serum testosterone level after single sildenafil treatment of adult male rats. Janjic MM, et al. J Sex Med, 2012 Oct. PMID 22429315
  4. Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle. Gerzanich V, et al. Circ Res, 2003 Oct 31. PMID 14512447
  5. Cyclic GMP signaling in rat urinary bladder, prostate, and epididymis: tissue-specific changes with aging and in response to Leydig cell depletion. Müller D, et al. Reproduction, 2011 Aug. PMID 21511885

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing of PKG1 Gene Mimics Effect of Aging and Sensitizes Rat Vascular Smooth Muscle Cells to Cardiotonic Steroids: Impact on Fibrosis and Salt Sensitivity.
    Title: Silencing of PKG1 Gene Mimics Effect of Aging and Sensitizes Rat Vascular Smooth Muscle Cells to Cardiotonic Steroids: Impact on Fibrosis and Salt Sensitivity.
  2. Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.
    Title: Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.
  3. melatonin ameliorated diabetic myocardial ischemia-reperfusion injury through cGMP-PKGIalpha, by modulating Nrf-2-HO-1 and MAPK signaling, thus reducing myocardial apoptosis and oxidative stress and preserving cardiac function
    Title: Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation.
  4. Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the iNOS and PKG-1 signaling pathway.
    Title: Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide synthase and cyclic guanosine monophosphate-dependent protein kinase type 1.
  5. These data suggest the involvement of calcium and PKGIalpha signaling in insulin-enhanced filtration barrier permeability in podocytes.
    Title: Intracellular calcium signaling regulates glomerular filtration barrier permeability: the role of the PKGIα-dependent pathway.
  6. During cGMP-mediated signaling, aa 888-928 of MYPT1 mediate the PKGIalpha-MYPT1 interaction.
    Title: MYPT1 mutants demonstrate the importance of aa 888-928 for the interaction with PKGIalpha.
  7. Our results demonstrate PKG-Ialpha might play an important role in the protective effects of scutellarin on endothelial dysfunction against myocardial ischemic reperfusion injury.
    Title: Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα.
  8. The Golgi apparatus regulates PKGIalpha compartmentation and proteolysis.
    Title: The Golgi apparatus regulates cGMP-dependent protein kinase I compartmentation and proteolysis.
  9. Tumor cell implantation into the tibia induced upregulation of cGKI messenger ribonucleic acid and protein in dorsal root ganglia and hyperexcitability in DRG neurons. Continuing activation of this pathway is needed for hyperalgesia and/or allodynia.
    Title: cGMP and cGMP-dependent protein kinase I pathway in dorsal root ganglia contributes to bone cancer pain in rats.
  10. these data indicate that heparin effects on vascular smooth muscle cell proliferation depend, at least in part, on signaling through protein kinase G.
    Title: Heparin responses in vascular smooth muscle cells involve cGMP-dependent protein kinase (PKG).
Submit: New GeneRIF Correction See all GeneRIFs (42)

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding ISO
Inferred from Sequence Orthology
more info
  
enables cGMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase p38 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendrite development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of large conductance calcium-activated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of testosterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within relaxation of vascular associated smooth muscle ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in vasodilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cGMP-dependent protein kinase 1
Names
cAMP-dependent protein kinase catalytic subunit PRKX-like
cGMP dependent protein kinase type 1
protein kinase, cGMP-dependent, type 1
protein kinase, cGMP-dependent, type I
NP_001099201.3
XP_063128022.1
XP_063128025.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105731.4 → NP_001099201.3  cGMP-dependent protein kinase 1

    See identical proteins and their annotated locations for NP_001099201.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ATM1, A9LNM8
    Related
    ENSRNOP00000111855.1, ENSRNOT00000166788.1
    Conserved Domains (4) summary
    cd12085
    Location:2 → 49
    DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha
    smart00133
    Location:621 → 664
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd00038
    Location:222 → 326
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:366 → 626
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    237818950..239052184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271952.1 → XP_063128022.1  cGMP-dependent protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9E8
    Related
    ENSRNOP00000090382.1, ENSRNOT00000091108.3

  2. XM_063271955.1 → XP_063128025.1  cGMP-dependent protein kinase 1 isoform X2

    Related
    ENSRNOP00000095894.1, ENSRNOT00000107140.2
Nucleotide Protein Strain
Heading Accession and Version

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