U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chrnd cholinergic receptor nicotinic delta subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 54240, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Chrndprovided by RGD
Official Full Name
cholinergic receptor nicotinic delta subunitprovided by RGD
Primary source
RGD:2352
See related
EnsemblRapid:ENSRNOG00000019527 AllianceGenome:RGD:2352
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 3A; congenital myasthenic syndrome 3B; and congenital myasthenic syndrome 3C. Orthologous to human CHRND (cholinergic receptor nicotinic delta subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 63.3), Testes (RPKM 5.3) and 2 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Chrnd in Genome Data Viewer
Location:
9q35
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95310316..95318734)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87862417..87870833)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94286550..94294968)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480403 Neighboring gene endothelin converting enzyme-like 1 Neighboring gene serine protease 56 Neighboring gene cholinergic receptor nicotinic gamma subunit Neighboring gene eukaryotic translation initiation factor 4E family member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy. Opella SJ, et al. Nat Struct Biol, 1999 Apr. PMID 10201407, Free PMC Article
  2. A 102 base pair sequence of the nicotinic acetylcholine receptor delta-subunit gene confers regulation by muscle electrical activity. Chahine KG, et al. Development, 1992 May. PMID 1638981
  3. Acetylcholine receptor delta subunit mutations underlie a fast-channel myasthenic syndrome and arthrogryposis multiplex congenita. Brownlow S, et al. J Clin Invest, 2001 Jul. PMID 11435464, Free PMC Article
  4. A novel mode-of-action mediated by the fetal muscle nicotinic acetylcholine receptor resulting in developmental toxicity in rats. Rasoulpour RJ, et al. Toxicol Sci, 2012 Jun. PMID 22461452
  5. Primary structure and functional expression of the alpha-, beta-, gamma-, delta- and epsilon-subunits of the acetylcholine receptor from rat muscle. Witzemann V, et al. Eur J Biochem, 1990 Dec 12. PMID 1702709

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to acetylcholine binding ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
acetylcholine receptor subunit delta
Names
cholinergic receptor, nicotinic delta
cholinergic receptor, nicotinic, delta (muscle)
cholinergic receptor, nicotinic, delta polypeptide
nicotinic acetylcholine receptor delta-subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019298.1 → NP_062171.1  acetylcholine receptor subunit delta precursor

    See identical proteins and their annotated locations for NP_062171.1

    Status: PROVISIONAL

    Source sequence(s)
    X74835
    UniProtKB/Swiss-Prot
    P25110
    UniProtKB/TrEMBL
    A6JWL0
    Related
    ENSRNOP00000026504.5, ENSRNOT00000026504.8
    Conserved Domains (3) summary
    TIGR00860
    Location:23 → 476
    LIC; Cation transporter family protein
    pfam02931
    Location:25 → 246
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:253 → 489
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    95310316..95318734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25110.1 GenPept UniProtKB/Swiss-Prot:P25110

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous