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Septin1 septin 1 [ Mus musculus (house mouse) ]

Gene ID: 54204, updated on 2-Nov-2024

Summary

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Official Symbol
Septin1provided by MGI
Official Full Name
septin 1provided by MGI
Primary source
MGI:MGI:1858916
See related
Ensembl:ENSMUSG00000000486 AllianceGenome:MGI:1858916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Diff6; Sept1; Pnutl3
Summary
Predicted to enable GTPase activity; identical protein binding activity; and molecular adaptor activity. Acts upstream of or within meiotic metaphase chromosome alignment and spindle assembly involved in female meiosis. Located in meiotic spindle and midbody. Is expressed in brain; cochlea; and thymus primordium. Orthologous to human SEPTIN1 (septin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 117.3), spleen adult (RPKM 47.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Septin1 in Genome Data Viewer
Location:
7 F3; 7 69.39 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126811881..126832157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127212709..127232985, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene TBC1 domain family, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene zinc finger protein 771

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Tooley AJ, et al. Nat Cell Biol, 2009 Jan. PMID 19043408, Free PMC Article
  2. Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences. Nottenburg C, et al. Gene, 1990 Nov 15. PMID 2174398
  3. Septin1 is required for spindle assembly and chromosome congression in mouse oocytes. Zhu J, et al. Dev Dyn, 2011 Oct. PMID 21932310
  4. Biochemical and morphological characterization of SEPT1 in mouse brain. Ito H, et al. Med Mol Morphol, 2020 Dec. PMID 32146512
  5. Localization of septin proteins in the mouse cochlea. Yoshida A, et al. Hear Res, 2012 Jul. PMID 22575789, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biochemical and morphological characterization of SEPT1 in mouse brain.
    Title: Biochemical and morphological characterization of SEPT1 in mouse brain.
  2. Results show that septin1 is a key player in spindle assembly and chromosome congression in mouse meiosis.
    Title: Septin1 is required for spindle assembly and chromosome congression in mouse oocytes.
  3. These data suggest that septins tune actomyosin forces during motility and probably regulate lymphocyte trafficking in confined tissues.
    Title: Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spindle assembly involved in female meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
septin-1
Names
differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase)
differentiation protein 6
peanut-like protein 3
protein Diff6
NP_059489.2
XP_006508092.1
XP_006508093.1
XP_006508094.1
XP_011240164.1
XP_036009143.1
XP_036009144.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017461.3 → NP_059489.2  septin-1

    See identical proteins and their annotated locations for NP_059489.2

    Status: VALIDATED

    Source sequence(s)
    AC122537
    Consensus CDS
    CCDS40141.1
    UniProtKB/Swiss-Prot
    B2RU74, P42209
    UniProtKB/TrEMBL
    A0A0U1RQA1
    Related
    ENSMUSP00000101921.2, ENSMUST00000106314.8
    Conserved Domains (2) summary
    COG5019
    Location:5 → 348
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00735
    Location:22 → 295
    Septin; Septin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126811881..126832157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508029.5 → XP_006508092.1  septin-1 isoform X1

    See identical proteins and their annotated locations for XP_006508092.1

    Conserved Domains (1) summary
    pfam00735
    Location:22 → 378
    Septin

  2. XM_011241862.2 → XP_011240164.1  septin-1 isoform X1

    See identical proteins and their annotated locations for XP_011240164.1

    Conserved Domains (1) summary
    pfam00735
    Location:22 → 378
    Septin

  3. XM_006508030.4 → XP_006508093.1  septin-1 isoform X2

    See identical proteins and their annotated locations for XP_006508093.1

    UniProtKB/TrEMBL
    A0A0U1RQA1, D3Z3V3
    Conserved Domains (1) summary
    pfam00735
    Location:1 → 274
    Septin

  4. XM_036153251.1 → XP_036009144.1  septin-1 isoform X4

    Conserved Domains (1) summary
    cl40481
    Location:11 → 119
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  5. XM_006508031.4 → XP_006508094.1  septin-1 isoform X2

    See identical proteins and their annotated locations for XP_006508094.1

    UniProtKB/TrEMBL
    A0A0U1RQA1, D3Z3V3
    Related
    ENSMUSP00000101920.2, ENSMUST00000106313.8
    Conserved Domains (1) summary
    pfam00735
    Location:1 → 274
    Septin

  6. XM_036153250.1 → XP_036009143.1  septin-1 isoform X3

    Conserved Domains (1) summary
    cl40481
    Location:23 → 296
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RNA

  1. XR_003946520.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42209.2 GenPept UniProtKB/Swiss-Prot:P42209

Gene LinkOut

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