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Rasa4 RAS p21 protein activator 4 [ Mus musculus (house mouse) ]

Gene ID: 54153, updated on 14-May-2024

Summary

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Official Symbol
Rasa4provided by MGI
Official Full Name
RAS p21 protein activator 4provided by MGI
Primary source
MGI:MGI:1858600
See related
Ensembl:ENSMUSG00000004952 AllianceGenome:MGI:1858600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAPL; CAPRI
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including cellular response to calcium ion; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to be located in cytosol. Predicted to colocalize with plasma membrane. Is expressed in trigeminal ganglion. Orthologous to several human genes including RASA4 (RAS p21 protein activator 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 17.6), spleen adult (RPKM 15.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Rasa4 in Genome Data Viewer
Location:
5 G2; 5 75.76 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136112775..136140714)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136083916..136111860)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene uroplakin 3B Neighboring gene uroplakin 3B-like Neighboring gene predicted gene, 40347 Neighboring gene STARR-positive B cell enhancer ABC_E2768 Neighboring gene STARR-seq mESC enhancer starr_14614 Neighboring gene microRNA 7035 Neighboring gene STARR-positive B cell enhancer ABC_E856 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide J Neighboring gene leucine-rich repeats and WD repeat domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6388

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. Zhang J, et al. Nat Immunol, 2005 Sep. PMID 16041389, Free PMC Article
  2. CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane. Strazza M, et al. J Immunol, 2015 Mar 15. PMID 25637021
  3. Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding. Hikita A, et al. J Biol Chem, 2005 Dec 16. PMID 16234249
  4. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities. Dai Y, et al. J Biol Chem, 2011 Jun 3. PMID 21460216, Free PMC Article
  5. Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Thomas JW, et al. Genome Res, 2000 May. PMID 10810084, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that calcium-promoted Ras inactivator (CAPRI) C2AB domains are required for CD28 antigen inhibition of adhesion.
    Title: CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.
  2. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities
    Title: Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.
  3. deltaCAPRI regulates RANKL shedding by modulating MMP14 expression through Ras signaling cascades other than the Erk pathway
    Title: Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0538

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein 4
Names
Ca2+promoted Ras inactivator
calcium-promoted RAS inactivator
rasGAP-activating-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039103.4 → NP_001034192.1  ras GTPase-activating protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001034192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC087420
    Consensus CDS
    CCDS39325.1
    UniProtKB/Swiss-Prot
    Q6PFQ7
    Related
    ENSMUSP00000098136.4, ENSMUST00000100570.10
    Conserved Domains (7) summary
    cd04054
    Location:6 → 126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    smart00323
    Location:245 → 558
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13372
    Location:495 → 634
    PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
    pfam00169
    Location:520 → 625
    PH; PH domain
    pfam00779
    Location:634 → 662
    BTK; BTK motif
    cl02569
    Location:264 → 503
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:134 → 256
    C2; C2 domain

  2. NM_133914.4 → NP_598675.2  ras GTPase-activating protein 4 isoform 1

    See identical proteins and their annotated locations for NP_598675.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087420
    Consensus CDS
    CCDS39324.1
    UniProtKB/Swiss-Prot
    Q2PMI6, Q3U2R4, Q571H1, Q58DY7, Q6PFQ7
    Related
    ENSMUSP00000037869.8, ENSMUST00000042135.14
    Conserved Domains (7) summary
    cd04054
    Location:6 → 126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    cd05395
    Location:264 → 549
    RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
    smart00323
    Location:245 → 604
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13372
    Location:541 → 680
    PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
    pfam00169
    Location:566 → 671
    PH; PH domain
    pfam00779
    Location:680 → 708
    BTK; BTK motif
    cl14603
    Location:134 → 256
    C2; C2 domain

RNA

  1. NR_189324.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087420

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136112775..136140714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165305.1 → XP_036021198.1  ras GTPase-activating protein 4 isoform X1

    Conserved Domains (3) summary
    pfam00779
    Location:330 → 358
    BTK; BTK motif
    cl02569
    Location:1 → 199
    RasGAP; Ras GTPase Activating Domain
    cl17171
    Location:191 → 330
    PH-like; Pleckstrin homology-like domain

  2. XM_036165304.1 → XP_036021197.1  ras GTPase-activating protein 4 isoform X1

    Conserved Domains (3) summary
    pfam00779
    Location:330 → 358
    BTK; BTK motif
    cl02569
    Location:1 → 199
    RasGAP; Ras GTPase Activating Domain
    cl17171
    Location:191 → 330
    PH-like; Pleckstrin homology-like domain

  3. XM_036165303.1 → XP_036021196.1  ras GTPase-activating protein 4 isoform X1

    Related
    ENSMUST00000135344.8
    Conserved Domains (3) summary
    pfam00779
    Location:330 → 358
    BTK; BTK motif
    cl02569
    Location:1 → 199
    RasGAP; Ras GTPase Activating Domain
    cl17171
    Location:191 → 330
    PH-like; Pleckstrin homology-like domain

  4. XM_036165306.1 → XP_036021199.1  ras GTPase-activating protein 4 isoform X1

    Conserved Domains (3) summary
    pfam00779
    Location:330 → 358
    BTK; BTK motif
    cl02569
    Location:1 → 199
    RasGAP; Ras GTPase Activating Domain
    cl17171
    Location:191 → 330
    PH-like; Pleckstrin homology-like domain

  5. XM_036165307.1 → XP_036021200.1  ras GTPase-activating protein 4 isoform X1

    Conserved Domains (3) summary
    pfam00779
    Location:330 → 358
    BTK; BTK motif
    cl02569
    Location:1 → 199
    RasGAP; Ras GTPase Activating Domain
    cl17171
    Location:191 → 330
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_001784726.2 RNA Sequence

    Related
    ENSMUST00000134509.8

  2. XR_377106.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFQ7.1 GenPept UniProtKB/Swiss-Prot:Q6PFQ7

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