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casp8ap2 caspase 8 associated protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 541521, updated on 2-Nov-2024

Summary

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Official Symbol
casp8ap2provided by ZNC
Official Full Name
caspase 8 associated protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030826-8
See related
Ensembl:ENSDARG00000022718 AllianceGenome:ZFIN:ZDB-GENE-030826-8
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
FLASH; fc74h10; wu:fc74h10; zgc:113449
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in Fas signaling pathway and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within apoptotic signaling pathway. Predicted to be located in nucleus. Predicted to be active in PML body and mitochondrion. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See casp8ap2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (23946992..23956014)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (24047892..24056914)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene katanin p60 (ATPase containing) subunit A 1 Neighboring gene midasin AAA ATPase 1 Neighboring gene gap junction protein alpha 10 b Neighboring gene BTB and CNC homology 1, basic leucine zipper transcription factor 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Correlated expression of retrocopies and parental genes in zebrafish. Zhong Z, et al. Mol Genet Genomics, 2016 Apr. PMID 26561303
  2. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Inohara N, et al. Cell Death Differ, 2000 May. PMID 10917738
  3. A subtracted cDNA library from the zebrafish (Danio rerio) embryonic inner ear. Coimbra RS, et al. Genome Res, 2002 Jun. PMID 12045154, Free PMC Article
  4. The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Luo Q, et al. J Fish Biol, 2016 Apr. PMID 26992035
  5. A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. Tiefenbach J, et al. PLoS One, 2010 Mar 22. PMID 20339547, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Fas signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CASP8-associated protein 2
Names
CASP8 associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014334.2 → NP_001014356.2  CASP8-associated protein 2

    Status: VALIDATED

    Source sequence(s)
    BX510339
    UniProtKB/TrEMBL
    A0A8M1N4R8, F1QB51, F1QD18
    Related
    ENSDARP00000120799.2, ENSDART00000144195.4
    Conserved Domains (1) summary
    cd12202
    Location:1927 → 1991
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    23946992..23956014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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