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Rdh7 retinol dehydrogenase 7 [ Mus musculus (house mouse) ]

Gene ID: 54150, updated on 2-Nov-2024

Summary

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Official Symbol
Rdh7provided by MGI
Official Full Name
retinol dehydrogenase 7provided by MGI
Primary source
MGI:MGI:1860517
See related
Ensembl:ENSMUSG00000040134 AllianceGenome:MGI:1860517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRAD2
Summary
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity; androstan-3-alpha,17-beta-diol dehydrogenase activity; and androsterone dehydrogenase activity. Predicted to be involved in retinol metabolic process and steroid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in alimentary system; intestine; liver; metanephros; and stomach. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 592.0) and liver E18 (RPKM 146.7) See more
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Genomic context

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See Rdh7 in Genome Data Viewer
Location:
10 D3; 10 76.39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127719896..127725116, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127884027..127889247, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 19 Neighboring gene RDH16 family member 2 Neighboring gene predicted gene, 31091 Neighboring gene STARR-seq mESC enhancer starr_28247 Neighboring gene STARR-seq mESC enhancer starr_28249 Neighboring gene 4short chain dehydrogenase/reductase family 9C, member 7 Neighboring gene STARR-seq mESC enhancer starr_28250 Neighboring gene predicted gene, 40804

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene structure and promoter for Crad2 encoding mouse cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme. Tomita K, et al. Gene, 2000 Jun 27. PMID 10876094
  2. cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme. Su J, et al. J Biol Chem, 1998 Jul 10. PMID 9651397
  3. Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis. Grizotte-Lake M, et al. Immunity, 2018 Dec 18. PMID 30566883, Free PMC Article
  4. Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally. Ulven SM, et al. Dev Dyn, 2001 Nov. PMID 11747070
  5. Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid. Ulven SM, et al. Dev Biol, 2000 Apr 15. PMID 10753524

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinol dehydrogenase 7
Names
CRAD-2
cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2
cis-retinol/androgen dehydrogenase type 2
NP_001144221.1
NP_059501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001150749.1 → NP_001144221.1  retinol dehydrogenase 7

    See identical proteins and their annotated locations for NP_001144221.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB015165, AI255893, CB951082, CJ097101
    Consensus CDS
    CCDS24255.1
    UniProtKB/Swiss-Prot
    O88451
    Related
    ENSMUSP00000039252.5, ENSMUST00000047199.5
    Conserved Domains (2) summary
    cd09805
    Location:30 → 305
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:30 → 217
    adh_short; short chain dehydrogenase

  2. NM_017473.4 → NP_059501.1  retinol dehydrogenase 7

    See identical proteins and their annotated locations for NP_059501.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA260496, AC131690, AF056194
    Consensus CDS
    CCDS24255.1
    UniProtKB/Swiss-Prot
    O88451
    Conserved Domains (2) summary
    cd09805
    Location:30 → 305
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:30 → 217
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127719896..127725116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88451.1 GenPept UniProtKB/Swiss-Prot:O88451

Gene LinkOut

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