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septin9b septin 9b [ Danio rerio (zebrafish) ]

Gene ID: 541494, updated on 2-Nov-2024

Summary

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Official Symbol
septin9bprovided by ZNC
Official Full Name
septin 9bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050327-17
See related
Ensembl:ENSDARG00000103900 AllianceGenome:ZFIN:ZDB-GENE-050327-17
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sept9b; zgc:113041
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in brachial plexus neuritis and colorectal cancer. Orthologous to human SEPTIN9 (septin 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See septin9b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (18937386..19035760, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (22466065..22564439, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6C2 Neighboring gene uncharacterized LOC137495951 Neighboring gene si:rp71-81e14.2 Neighboring gene si:ch211-188c18.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish possess two genes, sept9a and sept9b that, like humans, express multiple transcripts.
    Title: Alternative splicing of sept9a and sept9b in zebrafish produces multiple mRNA transcripts expressed throughout development.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
septin 9b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014307.3 → NP_001014329.1  septin 9b isoform c

    See identical proteins and their annotated locations for NP_001014329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AL954176
    UniProtKB/TrEMBL
    A0A2R8QDE4, A0A2R8QM64, Q58EK7
    Related
    ENSDARP00000135971.1, ENSDART00000170039.2
    Conserved Domains (2) summary
    cd01850
    Location:38 → 312
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:20 → 324
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  2. NM_001327974.1 → NP_001314903.1  septin 9b isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL954176, CR925723
    UniProtKB/TrEMBL
    A0A2R8Q8Y9, A0A8M1P8L4
    Related
    ENSDARP00000149599.1, ENSDART00000187714.1
    Conserved Domains (2) summary
    cd01850
    Location:262 → 536
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:244 → 548
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  3. NM_001327975.1 → NP_001314904.1  septin 9b isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL954176, CR925723
    UniProtKB/TrEMBL
    A0A2R8QHK6, A0A8M1P436
    Related
    ENSDARP00000153491.1, ENSDART00000184729.1
    Conserved Domains (2) summary
    cd01850
    Location:261 → 535
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:243 → 547
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  4. NM_001327977.1 → NP_001314906.1  septin 9b isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AL954176
    UniProtKB/TrEMBL
    A0A2R8QDE4, A0A2R8QM64, Q58EK7
    Related
    ENSDARP00000154121.1, ENSDART00000185278.1
    Conserved Domains (2) summary
    cd01850
    Location:38 → 312
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:20 → 324
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    18937386..19035760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394637.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    442729..543819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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