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CT45A6 cancer/testis antigen family 45 member A6 [ Homo sapiens (human) ]

Gene ID: 541465, updated on 28-Oct-2024

Summary

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Official Symbol
CT45A6provided by HGNC
Official Full Name
cancer/testis antigen family 45 member A6provided by HGNC
Primary source
HGNC:HGNC:33271
See related
Ensembl:ENSG00000278289 MIM:300797; AllianceGenome:HGNC:33271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT45-5; CT45-6; CT45.6; CT45A5; CT45A7
Expression
Restricted expression toward testis (RPKM 10.1) See more
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Genomic context

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See CT45A6 in Genome Data Viewer
Location:
Xq26.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135794685..135802787, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_004070887.1 (725828..733930, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A3 Neighboring gene cancer/testis antigen family 45 member A5 Neighboring gene cancer/testis antigen family 45 member A2 Neighboring gene cancer/testis antigen family 45 member A7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen YT, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905330, Free PMC Article
  2. Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression. Xiao W, et al. Autophagy, 2022 Nov. PMID 35253629, Free PMC Article
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression. Xu X, et al. BMC Cancer, 2022 Jun 8. PMID 35676659, Free PMC Article
  5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
cancer/testis antigen family 45 member A6
Names
Cancer/testis antigen 45-5
Cancer/testis antigen 45A5
Cancer/testis antigen 45A7
Cancer/testis antigen family 45 member A5
Cancer/testis antigen family 45 member A7
cancer/testis antigen 45-4/6
cancer/testis antigen 45-6
cancer/testis antigen 45A4/45A6
cancer/testis antigen 45A6
cancer/testis antigen CT45-6
cancer/testis antigen family 45 member A4/A6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017438.3 → NP_001017438.2  cancer/testis antigen family 45 member A6

    See identical proteins and their annotated locations for NP_001017438.2

    Status: VALIDATED

    Source sequence(s)
    AC240441
    Consensus CDS
    CCDS35407.1
    UniProtKB/Swiss-Prot
    P0DMU7, P0DMU8, P0DMV0
    Related
    ENSP00000479608.2, ENST00000620654.2
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    135794685..135802787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531351.3 → XP_011529653.1  cancer/testis antigen family 45 member A6 isoform X1

    See identical proteins and their annotated locations for XP_011529653.1

    UniProtKB/Swiss-Prot
    P0DMU7, P0DMU8, P0DMV0
    Related
    ENSP00000483910.1, ENST00000612878.4
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  2. XM_005262425.5 → XP_005262482.2  cancer/testis antigen family 45 member A6 isoform X1

    See identical proteins and their annotated locations for XP_005262482.2

    UniProtKB/Swiss-Prot
    P0DMU7, P0DMU8, P0DMV0
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DMU7.1 GenPept UniProtKB/Swiss-Prot:P0DMU7

Gene LinkOut

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