ugdh UDP-glucose 6-dehydrogenase [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: ugdhprovided by Xenbase
Official Full Name: UDP-glucose 6-dehydrogenaseprovided by Xenbase
Primary source: Xenbase:XB-GENE-950970
See related: Ensembl:ENSXETG00000012846 AllianceGenome:Xenbase:XB-GENE-950970
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: gdh; ugd; xugdh; udpgdh; ugdh-a; ugdh-b
Summary: Predicted to enable NAD binding activity and UDP-glucose 6-dehydrogenase activity. Predicted to act upstream of or within several processes, including UDP-glucuronate biosynthetic process; atrioventricular valve formation; and positive regulation of signal transduction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (36168395..36188486, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (27025241..27045539, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UDP-glucose dehydrogenase has a role in hyaluronan synthesis
Title: Molecular cloning and characterization of UDP-glucose dehydrogenase from the amphibian Xenopus laevis and its involvement in hyaluronan synthesis.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables UDP-glucose 6-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within UDP-glucuronate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within atrioventricular valve formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart valve formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucose 6-dehydrogenase

Names: UDP-glucose dehydrogenase

NP_001013628.1

EC 1.1.1.22

XP_012816965.1

EC 1.1.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.