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mapk7 mitogen-activated protein kinase 7 [ Danio rerio (zebrafish) ]

Gene ID: 541323, updated on 2-Nov-2024

Summary

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Official Symbol
mapk7provided by ZNC
Official Full Name
mitogen-activated protein kinase 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-10
See related
Ensembl:ENSDARG00000023110 AllianceGenome:ZFIN:ZDB-GENE-050320-10
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bmk1; erk5; fb73b02; wu:fb73b02; zgc:113111
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within cell-cell junction maintenance; digestive tract development; and ossification. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; gut; head; pronephric duct; and tail bud. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mapk7 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (4222854..4238827)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (4186094..4202062)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene dendrite extension defective protein 1-like Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene zgc:92313 Neighboring gene matrix metallopeptidase 25b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis. Gao W, et al. Hum Mutat, 2017 Nov. PMID 28714182
  2. Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis. Zhou T, et al. Cell Physiol Biochem, 2018. PMID 30032135
  3. Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling. Xie X, et al. Curr Mol Med, 2018. PMID 29577856
  4. The Progress of CRISPR/Cas9-Mediated Gene Editing in Generating Mouse/Zebrafish Models of Human Skeletal Diseases. Wu N, et al. Comput Struct Biotechnol J, 2019. PMID 31360334, Free PMC Article
  5. Erk5 functions in modulation of zebrafish intestinal permeability. Lv H, et al. Cell Tissue Res, 2023 Aug. PMID 37256363

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Erk5 functions in modulation of zebrafish intestinal permeability.
    Title: Erk5 functions in modulation of zebrafish intestinal permeability.
  2. The data suggest that flow-induced ERK5-klf2a-nos2b signaling is involved in CVP angiogenesis in zebrafish embryos.
    Title: Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell-cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ossification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 7
Names
extracellular signal-regulated kinase 5
NP_001013469.2
XP_005156059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013451.3 → NP_001013469.2  mitogen-activated protein kinase 7

    See identical proteins and their annotated locations for NP_001013469.2

    Status: VALIDATED

    Source sequence(s)
    AL954132, DQ360072
    UniProtKB/TrEMBL
    A0A8M1N4F1, Q0H1F4
    Related
    ENSDARP00000042276.5, ENSDART00000042277.7
    Conserved Domains (2) summary
    smart00220
    Location:80 → 373
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:74 → 410
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    4222854..4238827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156002.5 → XP_005156059.1  mitogen-activated protein kinase 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B237, E9QEY0
    Related
    ENSDARP00000119429.1, ENSDART00000133675.4
    Conserved Domains (2) summary
    smart00220
    Location:80 → 373
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:74 → 410
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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