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XBP1 X-box binding protein 1 [ Bos taurus (domestic cattle) ]

Gene ID: 541236, updated on 4-Oct-2024

Summary

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Official Symbol
XBP1provided by VGNC
Official Full Name
X-box binding protein 1provided by VGNC
Primary source
VGNC:VGNC:53930
See related
Ensembl:ENSBTAG00000005970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
XBPP1
Orthologs
human mouse all
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Genomic context

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See XBP1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (68052009..68057008, complement)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone Neighboring gene coiled-coil domain containing 117 Neighboring gene uncharacterized LOC101903066 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene coiled-coil domain-containing protein 117-like Neighboring gene TNFAIP3 interacting protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells. Sharmin MM, et al. J Dairy Sci, 2021 Nov. PMID 34364639
  2. Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization. Liu L, et al. Am J Pathol, 2013 Apr. PMID 23395094, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
    Title: Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
  2. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha and ATF6 arms of the unfolded protein response compared with untreated cells.
    Title: Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC127699

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
X-box-binding protein 1
Names
X-box binding protein pseudogene 1
XBP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034727.3 → NP_001029899.1  X-box-binding protein 1 isoform XBP1(U)

    See identical proteins and their annotated locations for NP_001029899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform, XBP1(U).
    Source sequence(s)
    DAAA02045588, EH145309, EH156163
    UniProtKB/Swiss-Prot
    Q3SZZ2
    UniProtKB/TrEMBL
    A0AAA9U020
    Related
    ENSBTAP00000102912.1, ENSBTAT00000114652.1
    Conserved Domains (1) summary
    cd14691
    Location:70 → 126
    bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain

  2. NM_001271737.1 → NP_001258666.1  X-box-binding protein 1 isoform XBP1(S)

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 26 nt segment in the CDS compared to variant 1, that causes a frameshift. The resulting isoform, XBP1(S), has the same N-terminus, but a longer and distinct C-terminus compared to isoform XBP1(U). Isoform XBP1(S) functions as a transcription factor.
    Source sequence(s)
    DAAA02045588, EH145309
    UniProtKB/TrEMBL
    A0A452DI37
    Related
    ENSBTAP00000007835.6, ENSBTAT00000007835.6
    Conserved Domains (1) summary
    cd14691
    Location:70 → 126
    bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    68052009..68057008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SZZ2.1 GenPept UniProtKB/Swiss-Prot:Q3SZZ2

Gene LinkOut

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Molecular Biology Databases
Research Materials