RIPK4 receptor interacting serine/threonine kinase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RIPK4provided by HGNC
Official Full Name: receptor interacting serine/threonine kinase 4provided by HGNC
Primary source: HGNC:HGNC:496
See related: Ensembl:ENSG00000183421 MIM:605706; AllianceGenome:HGNC:496
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DIK; PKK; PPS2; RIP4; ANKK2; NKRD3; ANKRD3; CHANDS
Summary: The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Expression: Broad expression in esophagus (RPKM 16.7), kidney (RPKM 9.9) and 16 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 21q22.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (41739373..41767052, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (40129762..40157439, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (43159533..43187212, complement)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer.
Title: m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer.
RIPK4 Promotes Cell Invasion and the Epithelial-Mesenchymal Transition in Ovarian Cancer.
Title: RIPK4 Promotes Cell Invasion and the Epithelial-Mesenchymal Transition in Ovarian Cancer.
LncRNA MIR31HG promotes cell proliferation and invasive properties of the MCF-7 cell line by regulation of receptor-interacting serine-threonine kinase 4.
Title: LncRNA MIR31HG promotes cell proliferation and invasive properties of the MCF-7 cell line by regulation of receptor-interacting serine-threonine kinase 4.
Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma.
Title: Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma.
RIPK4 regulates cell-cell adhesion in epidermal development and homeostasis.
Title: RIPK4 regulates cell-cell adhesion in epidermal development and homeostasis.
Receptor interacting protein kinase 4 promotes cell proliferation, migration, and invasion in ovarian cancer via targeting protein kinase C delta.
Title: Receptor interacting protein kinase 4 promotes cell proliferation, migration, and invasion in ovarian cancer via targeting protein kinase C delta.
Deciphering the Functional Role of RIPK4 in Melanoma.
Title: Deciphering the Functional Role of RIPK4 in Melanoma.
Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6.
Title: Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6.
MicroRNA miR-330-3p suppresses the progression of ovarian cancer by targeting RIPK4.
Title: MicroRNA miR-330-3p suppresses the progression of ovarian cancer by targeting RIPK4.
Overexpression of RIPK4 Predicts Poor Prognosis and Promotes Metastasis in Ovarian Cancer.
Title: Overexpression of RIPK4 Predicts Poor Prognosis and Promotes Metastasis in Ovarian Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Bartsocas-Papas syndrome 1 MedGen: C1849718 OMIM: 263650 GeneReviews: Not available	Compare labs
Curly hair, ankyloblepharon, nail dysplasia syndrome MedGen: C0406733 OMIM: 214350 GeneReviews: Not available	Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH99224 (e-PCR)
- UniSTS:91741

GDB:182516 (e-PCR)
- UniSTS:155384

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: receptor-interacting serine/threonine-protein kinase 4

Names: PKC-delta-interacting protein kinase; ankyrin repeat domain-containing protein 3; protein kinase C-associated kinase; serine/threonine-protein kinase ANKRD3

NP_065690.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032113.2 RefSeqGene

Range

5038..32717

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_020639.3 → NP_065690.2 receptor-interacting serine/threonine-protein kinase 4

See identical proteins and their annotated locations for NP_065690.2

Status: REVIEWED

Source sequence(s)

AJ278016, AK027424, BC035755, BM979316

Consensus CDS

CCDS13675.1

UniProtKB/TrEMBL

Q2TB16, Q9H4D1

Related

ENSP00000332454.3, ENST00000332512.8

Conserved Domains (5) summary

smart00221
Location:26 → 279

STYKc; Protein kinase; unclassified specificity

cd00204
Location:598 → 723

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14025
Location:25 → 290

STKc_RIP4_like; Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins

pfam12796
Location:608 → 699

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:603 → 634

ANK; ANK repeat [structural motif]