RIPK4 receptor interacting serine/threonine kinase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RIPK4provided by HGNC
Official Full Name: receptor interacting serine/threonine kinase 4provided by HGNC
Primary source: HGNC:HGNC:496
See related: Ensembl:ENSG00000183421 MIM:605706; AllianceGenome:HGNC:496
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DIK; PKK; PPS2; RIP4; ANKK2; NKRD3; ANKRD3; CHANDS
Summary: The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Expression: Broad expression in esophagus (RPKM 16.7), kidney (RPKM 9.9) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q22.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (41739373..41767052, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (40129762..40157439, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (43159533..43187212, complement)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSK3beta and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer.
Title: GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer.
The involvement of RIPK4 in TNF-alpha-stimulated IL-6 and IL-8 production by melanoma cells.
Title: The involvement of RIPK4 in TNF-α-stimulated IL-6 and IL-8 production by melanoma cells.
m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer.
Title: m6A-modified RIPK4 facilitates proliferation and cisplatin resistance in epithelial ovarian cancer.
RIPK4 Promotes Cell Invasion and the Epithelial-Mesenchymal Transition in Ovarian Cancer.
Title: RIPK4 Promotes Cell Invasion and the Epithelial-Mesenchymal Transition in Ovarian Cancer.
LncRNA MIR31HG promotes cell proliferation and invasive properties of the MCF-7 cell line by regulation of receptor-interacting serine-threonine kinase 4.
Title: LncRNA MIR31HG promotes cell proliferation and invasive properties of the MCF-7 cell line by regulation of receptor-interacting serine-threonine kinase 4.
Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma.
Title: Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma.
RIPK4 regulates cell-cell adhesion in epidermal development and homeostasis.
Title: RIPK4 regulates cell-cell adhesion in epidermal development and homeostasis.
Receptor interacting protein kinase 4 promotes cell proliferation, migration, and invasion in ovarian cancer via targeting protein kinase C delta.
Title: Receptor interacting protein kinase 4 promotes cell proliferation, migration, and invasion in ovarian cancer via targeting protein kinase C delta.
Deciphering the Functional Role of RIPK4 in Melanoma.
Title: Deciphering the Functional Role of RIPK4 in Melanoma.
Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6.
Title: Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Bartsocas-Papas syndrome 1 MedGen: C1849718 OMIM: 263650 GeneReviews: Not available	not available
Curly hair, ankyloblepharon, nail dysplasia syndrome MedGen: C0406733 OMIM: 214350 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH99224 (e-PCR)
- UniSTS:91741

GDB:182516 (e-PCR)
- UniSTS:155384

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skin development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-interacting serine/threonine-protein kinase 4

Names: PKC-delta-interacting protein kinase; ankyrin repeat domain-containing protein 3; protein kinase C-associated kinase; serine/threonine-protein kinase ANKRD3

NP_065690.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032113.2 RefSeqGene

Range

5038..32717

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_020639.3 → NP_065690.2 receptor-interacting serine/threonine-protein kinase 4

See identical proteins and their annotated locations for NP_065690.2

Status: REVIEWED

Source sequence(s)

AJ278016, AK027424, BC035755, BM979316

Consensus CDS

CCDS13675.1

UniProtKB/TrEMBL

Q2TB16, Q9H4D1

Related

ENSP00000332454.3, ENST00000332512.8

Conserved Domains (5) summary

smart00221
Location:26 → 279

STYKc; Protein kinase; unclassified specificity

cd00204
Location:598 → 723

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14025
Location:25 → 290

STKc_RIP4_like; Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins

pfam12796
Location:608 → 699

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:603 → 634

ANK; ANK repeat [structural motif]