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ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Bos taurus (domestic cattle) ]

Gene ID: 540568, updated on 4-Oct-2024

Summary

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Official Symbol
ATP2A2provided by VGNC
Official Full Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2provided by VGNC
Primary source
VGNC:VGNC:26291
See related
Ensembl:ENSBTAG00000001398
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ATP2A2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (54211193..54268644)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 81 Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene uncharacterized LOC100300938 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene microRNA mir-2285an Neighboring gene actin related protein 2/3 complex subunit 3 Neighboring gene GPN-loop GTPase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium. Ying G, et al. J Biol Chem, 2018 Nov 9. PMID 30228185, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cardiac muscle contraction by calcium ion signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Names
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
NP_001178359.1
XP_005217964.1
XP_024833179.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191430.1 → NP_001178359.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2

    See identical proteins and their annotated locations for NP_001178359.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000017
    UniProtKB/TrEMBL
    A0AAA9T933, F1MPR3
    Related
    ENSBTAP00000001838.5, ENSBTAT00000001838.6
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 961
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93 → 313
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:756 → 959
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:578 → 684
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:392 → 500
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    54211193..54268644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005217907.5 → XP_005217964.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LWF3, A0A3Q1M9U0
    Related
    ENSBTAP00000066955.2, ENSBTAT00000078158.2
    Conserved Domains (1) summary
    cd02083
    Location:5 → 988
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

  2. XM_024977411.2 → XP_024833179.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9SIU9, A0AAA9T933
    Related
    ENSBTAP00000083850.1, ENSBTAT00000089161.1
    Conserved Domains (1) summary
    cd02083
    Location:5 → 988
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials