MSN moesin [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: MSNprovided by VGNC
Official Full Name: moesinprovided by VGNC
Primary source: VGNC:VGNC:31703
See related: BGD:BT15527; Ensembl:ENSBTAG00000003418
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (94696645..94769333, complement)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study defines a novel role for the sphingosine kinase-S1P-ERM pathways in phosphate-induced vascular smooth muscle cells matrix mineralization and shows that blocking these pathways with pharmacological inhibitors reduces mineralization; these results may inform new therapeutic approaches to inhibit or delay vascular calcification
Title: Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.

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General gene information

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Markers

MSN (e-PCR)
- UniSTS:278791

MSN (e-PCR)
- UniSTS:498191

CC517135 (e-PCR)
- UniSTS:477246

BARC0037 (e-PCR)
- UniSTS:255319

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein localization to early endosome	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of organelle assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in apical part of cell	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info	PubMed
located_in microvillus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: moesin

Names: membrane-organizing extension spike protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001046477.1 → NP_001039942.1 moesin

See identical proteins and their annotated locations for NP_001039942.1

Status: PROVISIONAL

Source sequence(s)

BC113313

UniProtKB/Swiss-Prot

Q2HJ49

UniProtKB/TrEMBL

A0AAA9TIS4

Related

ENSBTAP00000017503.3, ENSBTAT00000017503.4

Conserved Domains (3) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 577

ERM; Ezrin/radixin/moesin family