GPT glutamic--pyruvic transaminase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GPTprovided by VGNC
Official Full Name: glutamic--pyruvic transaminaseprovided by VGNC
Primary source: VGNC:VGNC:29616
See related: BGD:BT17238; Ensembl:ENSBTAG00000007835
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	14	NC_037341.1 (438334..441339, complement)

Chromosome 14 - NC_037341.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study concludes that hepatic expression of alanine transaminase and glutathione synthetase (GS) are reduced in aged cows, and administration of 17beta-estradiol increases plasma estradiol and hepatic GS.
Title: Glutamine synthetase and alanine transaminase expression are decreased in livers of aged vs. young beef cows and GS can be upregulated by 17β-estradiol implants.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: alanine aminotransferase 1

Names: ALT1; GPT 1; glutamate pyruvate transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1

NP_001077209.1

EC 2.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083740.2 → NP_001077209.1 alanine aminotransferase 1

See identical proteins and their annotated locations for NP_001077209.1

Status: PROVISIONAL

Source sequence(s)

BC134583

UniProtKB/Swiss-Prot

A4IFH5

Related

ENSBTAP00000079284.1, ENSBTAT00000089844.1

Conserved Domains (2) summary

cd00609
Location:96 → 486

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

PTZ00377
Location:19 → 496

PTZ00377; alanine aminotransferase; Provisional