PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PRKAA2provided by VGNC
Official Full Name: protein kinase AMP-activated catalytic subunit alpha 2provided by VGNC
Primary source: VGNC:VGNC:50249
See related: BGD:BT22844; Ensembl:ENSBTAG00000018747
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (89470349..89549670, complement)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK).
Title: Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium.
The investigation of PRKAA2 genetic polymorphisms in three Chinese indigenous bovine breeds [Qinchuan (n = 328), Nanyang (n = 278), Jiaxian (n = 148)] and yak (n = 57), is reported.
Title: SNP discovery and haplotype analysis in the bovine PRKAA2 gene.
These data show that the AMPK activator AICAR is inhibitory to nuclear maturation in bovine oocytes due to activation of AMPK [AMP-activated protein kinase alpha 1 subunit].
Title: Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5'-AMP-activated protein kinase catalytic subunit alpha-2

Names: AMPK-activated protein kinase alpha-2 subunit

NP_001192534.1

EC 2.7.1.-

EC 2.7.11.1

EC 2.7.11.31

XP_024845372.1

EC 2.7.1.-

EC 2.7.11.1

EC 2.7.11.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205605.1 → NP_001192534.1 5'-AMP-activated protein kinase catalytic subunit alpha-2

See identical proteins and their annotated locations for NP_001192534.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000003

UniProtKB/TrEMBL

A0AAA9SU81, F1MQV7

Related

ENSBTAP00000088890.1, ENSBTAT00000130364.1

Conserved Domains (3) summary

cd12200
Location:395 → 550

AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha

cd14404
Location:285 → 349

UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)

cd14079
Location:13 → 268

STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

Range

89470349..89549670 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024989604.2 → XP_024845372.1 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1

Conserved Domains (3) summary

cd12200
Location:305 → 460

AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha

cd14404
Location:195 → 259

UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)

cl21453
Location:1 → 178

PKc_like; Protein Kinases, catalytic domain