Cdkl2 cyclin dependent kinase like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdkl2provided by MGI
Official Full Name: cyclin dependent kinase like 2provided by MGI
Primary source: MGI:MGI:1858227
See related: Ensembl:ENSMUSG00000029403 AllianceGenome:MGI:1858227
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kkm; KKIAMRE; 5330436L21Rik
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; male reproductive gland or organ; metanephros; and parathyroid gland. Orthologous to human CDKL2 (cyclin dependent kinase like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 6.7), CNS E18 (RPKM 3.6) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E2; 5 45.73 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (92153933..92198479, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (92006074..92043042, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cdkl2 functions mainly in mature neurons and that mechanisms governing regulation of this gene expression in mice are distinct from those of immediate-early genes.
Title: Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

AI505225 (e-PCR)
- UniSTS:179202

RH135504 (e-PCR)
- UniSTS:164877

NoName (e-PCR)
- UniSTS:235218

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-dependent kinase-like 2

Names: cyclin dependent kinase like 2 (CDC2 related kinase)

NP_001263244.1

EC 2.7.11.22

NP_058608.1

EC 2.7.11.22

NP_796244.2

EC 2.7.11.22

XP_011247839.1

EC 2.7.11.22

XP_011247840.1

EC 2.7.11.22

XP_011247841.1

EC 2.7.11.22

XP_017176476.1

EC 2.7.11.22

XP_017176477.1

EC 2.7.11.22

XP_017176479.1

EC 2.7.11.22

XP_036021189.1

EC 2.7.11.22

XP_036021190.1

EC 2.7.11.22

XP_036021191.1

EC 2.7.11.22

XP_036021192.1

EC 2.7.11.22

XP_036021193.1

EC 2.7.11.22

XP_036021194.1

EC 2.7.11.22

XP_036021195.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276315.1 → NP_001263244.1 cyclin-dependent kinase-like 2 isoform 2

See identical proteins and their annotated locations for NP_001263244.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2, also known as gamma) which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AB029066, AK030598, AK139820, BB616412, CD348339

Consensus CDS

CCDS19425.1

UniProtKB/Swiss-Prot

Q9QUK0

Related

ENSMUSP00000108768.2, ENSMUST00000113143.8

Conserved Domains (2) summary

smart00220
Location:4 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
NM_016912.2 → NP_058608.1 cyclin-dependent kinase-like 2 isoform 1

See identical proteins and their annotated locations for NP_058608.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1, also known as beta).

Source sequence(s)

AB029065, AB029066, AC165433, CD348339, CJ047658

Consensus CDS

CCDS19426.1

UniProtKB/Swiss-Prot

Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2

UniProtKB/TrEMBL

Q149A0

Related

ENSMUSP00000084199.6, ENSMUST00000086978.12

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
NM_177270.4 → NP_796244.2 cyclin-dependent kinase-like 2 isoform 2

See identical proteins and their annotated locations for NP_796244.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2, also known as gamma) which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AB029066, AC165433, CD348339, CJ047658

Consensus CDS

CCDS19425.1

UniProtKB/Swiss-Prot

Q9QUK0

Related

ENSMUSP00000063617.5, ENSMUST00000069937.11

Conserved Domains (2) summary

smart00220
Location:4 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

92153933..92198479 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165300.1 → XP_036021193.1 cyclin-dependent kinase-like 2 isoform X6

Conserved Domains (1) summary

cl21453
Location:2 → 224

PKc_like; Protein Kinases, catalytic domain
XM_036165297.1 → XP_036021190.1 cyclin-dependent kinase-like 2 isoform X2

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_036165299.1 → XP_036021192.1 cyclin-dependent kinase-like 2 isoform X4

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_017320987.3 → XP_017176476.1 cyclin-dependent kinase-like 2 isoform X1

UniProtKB/Swiss-Prot

Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2

UniProtKB/TrEMBL

Q149A0

Related

ENSMUSP00000108765.2, ENSMUST00000113140.5

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_036165298.1 → XP_036021191.1 cyclin-dependent kinase-like 2 isoform X4

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_011249538.3 → XP_011247840.1 cyclin-dependent kinase-like 2 isoform X3

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_011249537.4 → XP_011247839.1 cyclin-dependent kinase-like 2 isoform X1

See identical proteins and their annotated locations for XP_011247839.1

UniProtKB/Swiss-Prot

Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2

UniProtKB/TrEMBL

Q149A0

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_017320988.2 → XP_017176477.1 cyclin-dependent kinase-like 2 isoform X1

UniProtKB/Swiss-Prot

Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2

UniProtKB/TrEMBL

Q149A0

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_036165301.1 → XP_036021194.1 cyclin-dependent kinase-like 2 isoform X7

Conserved Domains (1) summary

cl21453
Location:2 → 224

PKc_like; Protein Kinases, catalytic domain
XM_036165296.1 → XP_036021189.1 cyclin-dependent kinase-like 2 isoform X2

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_011249539.3 → XP_011247841.1 cyclin-dependent kinase-like 2 isoform X5

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_036165302.1 → XP_036021195.1 cyclin-dependent kinase-like 2 isoform X9

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
XM_017320990.3 → XP_017176479.1 cyclin-dependent kinase-like 2 isoform X8

Conserved Domains (1) summary

cd07846
Location:2 → 289

STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3