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DARS2 aspartyl-tRNA synthetase 2, mitochondrial [ Bos taurus (domestic cattle) ]

Gene ID: 538772, updated on 4-Oct-2024

Summary

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Official Symbol
DARS2provided by VGNC
Official Full Name
aspartyl-tRNA synthetase 2, mitochondrialprovided by VGNC
Primary source
VGNC:VGNC:27882
See related
BGD:BT28128; Ensembl:ENSBTAG00000004358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See DARS2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (55204225..55232011)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 45 Neighboring gene kelch like family member 20 Neighboring gene centromere protein L Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene uncharacterized LOC100848315 Neighboring gene small nucleolar RNA SNORD81 Neighboring gene small nucleolar RNA SNORD47

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC157196

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables aspartate-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aspartyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aspartate--tRNA ligase, mitochondrial
Names
aspRS
aspartyl-tRNA synthetase, mitochondrial
NP_001095692.1
XP_005217160.1
XP_005217161.1
XP_010811649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102222.1 → NP_001095692.1  aspartate--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001095692.1

    Status: PROVISIONAL

    Source sequence(s)
    BC149492
    UniProtKB/Swiss-Prot
    A6QPU5
    UniProtKB/TrEMBL
    A0AAA9S1D9
    Related
    ENSBTAP00000005704.5, ENSBTAT00000005704.6
    Conserved Domains (4) summary
    PRK00476
    Location:47 → 633
    aspS; aspartyl-tRNA synthetase; Validated
    cd00777
    Location:184 → 606
    AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
    cd04317
    Location:47 → 180
    EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
    pfam02938
    Location:359 → 449
    GAD; GAD domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55204225..55232011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010813347.4 → XP_010811649.1  aspartate--tRNA ligase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_010811649.1

    UniProtKB/TrEMBL
    A0AAA9S1D9, F1MEQ5
    Conserved Domains (4) summary
    PRK00476
    Location:47 → 633
    aspS; aspartyl-tRNA synthetase; Validated
    cd00777
    Location:184 → 606
    AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
    cd04317
    Location:47 → 180
    EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
    pfam02938
    Location:359 → 449
    GAD; GAD domain

  2. XM_005217104.4 → XP_005217161.1  aspartate--tRNA ligase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005217161.1

    UniProtKB/TrEMBL
    A0AAA9S1D9, F1MEQ5
    Conserved Domains (4) summary
    PRK00476
    Location:47 → 633
    aspS; aspartyl-tRNA synthetase; Validated
    cd00777
    Location:184 → 606
    AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
    cd04317
    Location:47 → 180
    EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
    pfam02938
    Location:359 → 449
    GAD; GAD domain

  3. XM_005217103.5 → XP_005217160.1  aspartate--tRNA ligase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005217160.1

    UniProtKB/TrEMBL
    A0AAA9S1D9, F1MEQ5
    Conserved Domains (4) summary
    PRK00476
    Location:47 → 633
    aspS; aspartyl-tRNA synthetase; Validated
    cd00777
    Location:184 → 606
    AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
    cd04317
    Location:47 → 180
    EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
    pfam02938
    Location:359 → 449
    GAD; GAD domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6QPU5.1 GenPept UniProtKB/Swiss-Prot:A6QPU5

Gene LinkOut

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