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IL20RB interleukin 20 receptor subunit beta [ Homo sapiens (human) ]

Gene ID: 53833, updated on 11-Apr-2024

Summary

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Official Symbol
IL20RBprovided by HGNC
Official Full Name
interleukin 20 receptor subunit betaprovided by HGNC
Primary source
HGNC:HGNC:6004
See related
Ensembl:ENSG00000174564 MIM:605621; AllianceGenome:HGNC:6004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIRS1; FNDC6; IL-20R2
Summary
IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Expression
Biased expression in skin (RPKM 54.3) and esophagus (RPKM 20.8) See more
Orthologs
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Genomic context

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Location:
3q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (136957983..137011085)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (139698644..139751732)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136676825..136729927)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136587915-136588414 Neighboring gene solute carrier family 35 member G2 Neighboring gene NCK1 divergent transcript Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene MPRA-validated peak4840 silencer Neighboring gene NCK adaptor protein 1 Neighboring gene IL20RB antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 14292 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136725903-136726404 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:136741910-136742410 Neighboring gene MPRA-validated peak4841 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:136751222-136752088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:136930163-136930662 Neighboring gene VISTA enhancer hs208 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:137038167-137039366 Neighboring gene VISTA enhancer hs209 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:137050490-137051689 Neighboring gene VISTA enhancer hs210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:137179051-137179600 Neighboring gene VISTA enhancer hs653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20598 Neighboring gene RNA, 5S ribosomal pseudogene 142 Neighboring gene MTCH2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma. Zhang H, et al. BMC Genom Data, 2022 Jul 26. PMID 35883015, Free PMC Article
  2. Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma. Keller KE, et al. J Ocul Pharmacol Ther, 2014 Mar-Apr. PMID 24455976, Free PMC Article
  3. IL-20: biological functions and clinical implications. Wei CC, et al. J Biomed Sci, 2006 Sep. PMID 16703417
  4. Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Logsdon NJ, et al. Proc Natl Acad Sci U S A, 2012 Jul 31. PMID 22802649, Free PMC Article
  5. Association analysis of IL20RA and IL20RB genes in psoriasis. Kingo K, et al. Genes Immun, 2008 Jul. PMID 18480827

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma.
    Title: Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma.
  2. Trabecular meshwork cells express IL-20 receptors; Mutation of the T104 residue in IL-20R2 leads to a reduction in STAT3 phosphorylation as well as decreased matrix metalloproteinase activity
    Title: Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma.
  3. The crystal structure of the IL-20/IL-20R1/IL-20R2 complex reveals how type I and II complexes discriminate cognate from noncognate ligands
    Title: Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.
  4. crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%
    Title: Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.
  5. Complete mda-7/IL-24 receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) are seldom expressed in liver cancer cell lines.
    Title: Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines.
  6. The hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis and single nucleotide polymorphisms (SNPs) in the IL20RA and IL20RB genes in psoriasis patients were investigated.
    Title: Association analysis of IL20RA and IL20RB genes in psoriasis.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association analysis of IL20RA and IL20RB genes in psoriasis.
  8. forms stable complex with interleukin-19 and interleukin-20 [IL-20R1][IL-20R2]
    Title: Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association study of co-occurring anxiety in major depression.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC34923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-20 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response-inhibiting signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type IV hypersensitivity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-20 receptor subunit beta
Names
IL-20 receptor subunit beta
IL-20R-beta
IL-20RB
fibronectin type III domain containing 6
interleukin 20 receptor beta subunit
interleukin-20 receptor II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144717.4 → NP_653318.2  interleukin-20 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_653318.2

    Status: VALIDATED

    Source sequence(s)
    AY358305, BC063696
    Consensus CDS
    CCDS3093.1
    UniProtKB/Swiss-Prot
    B4DL40, Q6P438, Q6UXL0, Q8IYY5, Q8TAJ7
    Related
    ENSP00000328133.4, ENST00000329582.9
    Conserved Domains (2) summary
    pfam01108
    Location:30 → 124
    Tissue_fac; Tissue factor
    cl21522
    Location:136 → 225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    136957983..137011085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512911.3 → XP_011511213.1  interleukin-20 receptor subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011511213.1

    Conserved Domains (1) summary
    cl21522
    Location:1 → 77
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_011512910.4 → XP_011511212.1  interleukin-20 receptor subunit beta isoform X1

    Conserved Domains (2) summary
    pfam01108
    Location:35 → 129
    Tissue_fac; Tissue factor
    cl21522
    Location:141 → 230
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_017006632.1 → XP_016862121.1  interleukin-20 receptor subunit beta isoform X2

    Conserved Domains (1) summary
    cl21522
    Location:1 → 77
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_006713665.5 → XP_006713728.1  interleukin-20 receptor subunit beta isoform X2

    See identical proteins and their annotated locations for XP_006713728.1

    Conserved Domains (1) summary
    cl21522
    Location:1 → 77
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    139698644..139751732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346901.1 → XP_054202876.1  interleukin-20 receptor subunit beta isoform X2

  2. XM_054346900.1 → XP_054202875.1  interleukin-20 receptor subunit beta isoform X1

  3. XM_054346903.1 → XP_054202878.1  interleukin-20 receptor subunit beta isoform X2

  4. XM_054346902.1 → XP_054202877.1  interleukin-20 receptor subunit beta isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXL0.1 GenPept UniProtKB/Swiss-Prot:Q6UXL0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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