U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR84 G protein-coupled receptor 84 [ Homo sapiens (human) ]

Gene ID: 53831, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
GPR84provided by HGNC
Official Full Name
G protein-coupled receptor 84provided by HGNC
Primary source
HGNC:HGNC:4535
See related
Ensembl:ENSG00000139572 MIM:606383; AllianceGenome:HGNC:4535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EX33; GPCR4
Summary
Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 5.7), appendix (RPKM 3.3) and 6 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GPR84 in Genome Data Viewer
Location:
12q13.13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (54350698..54364486, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (54317281..54331118, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54756229..54758270, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene RNA, 7SL, cytoplasmic 744, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54750728-54751553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54751554-54752378 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:54752379-54753203 Neighboring gene GPR84, ZNF385A, ITGA5 and GTSF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6441 Neighboring gene zinc finger protein 385A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:54781074-54781708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:54781709-54782342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4529 Neighboring gene integrin subunit alpha 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54805235-54806017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54806018-54806799

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor? Luscombe VB, et al. DNA Cell Biol, 2020 Nov. PMID 33001759
  2. Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression. Müller MM, et al. Sci Rep, 2017 Apr 12. PMID 28404994, Free PMC Article
  3. Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84. Nikaido Y, et al. J Biochem, 2015 May. PMID 25425658
  4. GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis. Dietrich PA, et al. Blood, 2014 Nov 20. PMID 25293777
  5. Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells. Peters A, et al. Pharmacol Res, 2022 Feb. PMID 34968686

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.
    Title: Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.
  2. Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells.
    Title: Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells.
  3. Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
    Title: Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
  4. The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
    Title: The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
  5. Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.
    Title: Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.
  6. 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor?
    Title: 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor?
  7. Has a strong stimulatory effect on the expression of cytokine and chemokine genes, particularly CSF3, and on the expression of GPR84, a pro-inflammatory fatty acid receptor.
    Title: IL-33 stimulates expression of the GPR84 (EX33) fatty acid receptor gene and of cytokine and chemokine genes in human adipocytes.
  8. GPR84 modulates TNFalpha mRNA expression in the LPS tolerant monocytes.
    Title: Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression.
  9. we show functional similarities but also some important differences between GPR84 and FFA2R in human phagocytes, thus providing some mechanistic insights into GPR84 regulation in blood neutrophils and cells recruited to an aseptic inflammatory site in vivo.
    Title: Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R.
  10. Data suggest that cytokines TNFalpha and interleukin-1b markedly reduce GPR120/FFAR4 expression in adipocytes; in contrast, these cytokines induce expression of GPR84 and GPR41/FFAR3 in adipocytes. These studies were conducted in adipocytes cultured from subcutaneous adipose tissue. (GPR = G-protein coupled receptor; FFAR = free fatty acid receptor)
    Title: IL-1β and TNFα inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables urotensin II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptor 84
Names
inflammation-related G protein-coupled receptor EX33

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020370.3 → NP_065103.1  G-protein coupled receptor 84

    See identical proteins and their annotated locations for NP_065103.1

    Status: VALIDATED

    Source sequence(s)
    BC020614, BP303386, CD366881
    Consensus CDS
    CCDS8878.1
    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
    UniProtKB/TrEMBL
    A8K2X9
    Related
    ENSP00000267015.3, ENST00000267015.4
    Conserved Domains (1) summary
    cd15210
    Location:21 → 381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    54350698..54364486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429017.1 → XP_047284973.1  G-protein coupled receptor 84 isoform X2

  2. XM_011538495.3 → XP_011536797.1  G-protein coupled receptor 84 isoform X1

    See identical proteins and their annotated locations for XP_011536797.1

    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
    UniProtKB/TrEMBL
    A8K2X9
    Conserved Domains (1) summary
    cd15210
    Location:21 → 381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    54317281..54331118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372309.1 → XP_054228284.1  G-protein coupled receptor 84 isoform X2

  2. XM_054372308.1 → XP_054228283.1  G-protein coupled receptor 84 isoform X1

    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQS5.1 GenPept UniProtKB/Swiss-Prot:Q9NQS5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous