INPP5B inositol polyphosphate-5-phosphatase B [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: INPP5Bprovided by VGNC
Official Full Name: inositol polyphosphate-5-phosphatase Bprovided by VGNC
Primary source: VGNC:VGNC:30211
See related: Ensembl:ENSBTAG00000024107
Gene type: protein coding
RefSeq status: MODEL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (108007152..108061926)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BARC0024 (e-PCR)
- UniSTS:255310

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: type II inositol 1,4,5-trisphosphate 5-phosphatase

Names: inositol polyphosphate-5-phosphatase, 75kDa

XP_002686512.2

EC 3.1.3.36

XP_010802104.1

EC 3.1.3.36

XP_024845993.1

EC 3.1.3.36

XP_059741176.1

EC 3.1.3.36

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

Range

108007152..108061926

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002686466.6 → XP_002686512.2 type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

See identical proteins and their annotated locations for XP_002686512.2

UniProtKB/TrEMBL

A0A3Q1MBC9

Related

ENSBTAP00000060933.2, ENSBTAT00000067907.2

Conserved Domains (3) summary

cd09093
Location:267 → 560

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:694 → 911

RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...

pfam16776
Location:6 → 149

INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain
XM_059885193.1 → XP_059741176.1 type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2

UniProtKB/TrEMBL

E1BB73
XM_010803802.3 → XP_010802104.1 type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X3

See identical proteins and their annotated locations for XP_010802104.1

UniProtKB/TrEMBL

E1BB73

Related

ENSBTAP00000033176.6, ENSBTAT00000033256.6

Conserved Domains (2) summary

cd09093
Location:105 → 398

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:532 → 749

RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
XM_024990225.2 → XP_024845993.1 type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X4

UniProtKB/TrEMBL

E1BB73

Conserved Domains (2) summary

cd09093
Location:45 → 338

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:472 → 689

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...