U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MAP3K5 mitogen-activated protein kinase kinase kinase 5 [ Bos taurus (domestic cattle) ]

Gene ID: 537380, updated on 4-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
MAP3K5provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 5provided by VGNC
Primary source
VGNC:VGNC:31198
See related
BGD:BT19383; Ensembl:ENSBTAG00000009065
Gene type
protein coding
RefSeq status
INFERRED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ASK1
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MAP3K5 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (74542301..74770948, complement)

Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 639-like Neighboring gene microtubule associated protein 7 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene solute carrier family 35 member D3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. Li X, et al. J Biol Chem, 2005 Apr 15. PMID 15701637
  2. Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Zhang R, et al. Oncogene, 2005 Jun 2. PMID 15782121
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase kinase kinase 5
Names
apoptosis signal-regulating kinase 1
NP_001137553.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144081.2 → NP_001137553.2  mitogen-activated protein kinase kinase kinase 5

    Status: INFERRED

    Source sequence(s)
    NKLS02000009
    UniProtKB/TrEMBL
    A0AAA9RXG7, F1MXH6
    Related
    ENSBTAP00000011949.5, ENSBTAT00000011949.6
    Conserved Domains (2) summary
    cd06624
    Location:663 → 930
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:157 → 536
    DUF4071; Domain of unknown function (DUF4071)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    74542301..74770948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials