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APOA4 apolipoprotein A4 [ Bos taurus (domestic cattle) ]

Gene ID: 537301, updated on 10-Oct-2024

Summary

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Official Symbol
APOA4provided by VGNC
Official Full Name
apolipoprotein A4provided by VGNC
Primary source
VGNC:VGNC:26024
See related
BGD:BT16567; Ensembl:ENSBTAG00000019770
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See APOA4 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (27477953..27490905, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3B subunit 4-like Neighboring gene apolipoprotein A5 Neighboring gene apolipoprotein C-III Neighboring gene uncharacterized LOC104974207 Neighboring gene apolipoprotein C3 Neighboring gene apolipoprotein A1 Neighboring gene SIK family kinase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC127813

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cholesterol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylcholine-sterol O-acyltransferase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cholesterol efflux IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in high-density lipoprotein particle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid efflux IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in reverse cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in triglyceride homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in very-low-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of chylomicron IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
apolipoprotein A-IV
Names
apo-AIV
apoA-IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037480.1 → NP_001032557.1  apolipoprotein A-IV precursor

    See identical proteins and their annotated locations for NP_001032557.1

    Status: PROVISIONAL

    Source sequence(s)
    BC108096
    UniProtKB/Swiss-Prot
    Q32PJ2
    UniProtKB/TrEMBL
    A0A3Q1M3N0
    Conserved Domains (3) summary
    pfam01442
    Location:66 → 235
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02601
    Location:137 → 201
    Exonuc_VII_L; Exonuclease VII, large subunit
    cl19726
    Location:66 → 182
    DUF2884; Protein of unknown function (DUF2884)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    27477953..27490905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005215852.5 → XP_005215909.1  apolipoprotein A-IV isoform X1

    See identical proteins and their annotated locations for XP_005215909.1

    UniProtKB/TrEMBL
    A0A3Q1M3N0
    Related
    ENSBTAP00000068128.1, ENSBTAT00000086907.2
    Conserved Domains (3) summary
    pfam01442
    Location:91 → 260
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl19726
    Location:91 → 207
    DUF2884; Protein of unknown function (DUF2884)
    cl21509
    Location:207 → 314
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  2. XM_010812370.4 → XP_010810672.1  apolipoprotein A-IV isoform X1

    See identical proteins and their annotated locations for XP_010810672.1

    UniProtKB/TrEMBL
    A0A3Q1M3N0
    Related
    ENSBTAP00000026345.5, ENSBTAT00000026345.5
    Conserved Domains (3) summary
    pfam01442
    Location:91 → 260
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl19726
    Location:91 → 207
    DUF2884; Protein of unknown function (DUF2884)
    cl21509
    Location:207 → 314
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  3. XM_015474619.3 → XP_015330105.1  apolipoprotein A-IV isoform X2

    UniProtKB/TrEMBL
    A0A3Q1M3N0
    Conserved Domains (1) summary
    pfam01442
    Location:66 → 235
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  4. XM_059874884.1 → XP_059730867.1  apolipoprotein A-IV isoform X2

  5. XM_059874885.1 → XP_059730868.1  apolipoprotein A-IV isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32PJ2.1 GenPept UniProtKB/Swiss-Prot:Q32PJ2

Gene LinkOut

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Molecular Biology Databases
Research Materials