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LPIN1 lipin 1 [ Bos taurus (domestic cattle) ]

Gene ID: 537224, updated on 10-Oct-2024

Summary

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Official Symbol
LPIN1provided by VGNC
Official Full Name
lipin 1provided by VGNC
Primary source
VGNC:VGNC:30966
See related
Ensembl:ENSBTAG00000007689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
lipin1
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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Genomic context

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See LPIN1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (86081383..86211611, complement)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346621 Neighboring gene uncharacterized LOC112448828 Neighboring gene uncharacterized LOC132346622 Neighboring gene neurotensin receptor 2 Neighboring gene growth regulating estrogen receptor binding 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LPIN1 promotes triglycerides synthesis and is transcriptionally regulated by PPARG in buffalo mammary epithelial cells. Zhou F, et al. Sci Rep, 2022 Feb 11. PMID 35149744, Free PMC Article
  2. Genetic Effects of LPIN1 Polymorphisms on Milk Production Traits in Dairy Cattle. Han B, et al. Genes (Basel), 2019 Apr 2. PMID 30986988, Free PMC Article
  3. ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation. Bionaz M, et al. J Nutr, 2008 Jun. PMID 18492828
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPIN1 promotes triglycerides synthesis and is transcriptionally regulated by PPARG in buffalo mammary epithelial cells.
    Title: LPIN1 promotes triglycerides synthesis and is transcriptionally regulated by PPARG in buffalo mammary epithelial cells.
  2. we demonstrated the significant genetic effects of LPIN1 on milk production traits, and the identified SNPs could serve as genetic markers for dairy breeding
    Title: Genetic Effects of LPIN1 Polymorphisms on Milk Production Traits in Dairy Cattle.
  3. The results of this study suggest that suggest that SLC27A6, ACSL1, FABP3, AGPAT6, and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
    Title: ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidate phosphatase LPIN1
NP_001193085.2
XP_024854669.1
XP_024854670.1
XP_024854671.1
XP_024854675.1
XP_059747343.1
XP_059747345.1
XP_059747346.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206156.2 → NP_001193085.2  phosphatidate phosphatase LPIN1

    Status: VALIDATED

    Source sequence(s)
    DAAA02031896, DAAA02031897, DT861783, DV839683, EV796814, GH304799
    UniProtKB/TrEMBL
    A0A3Q1MY10, E1BPE8
    Related
    ENSBTAP00000098419.1, ENSBTAT00000103752.1
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:666 → 891
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:504 → 594
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    86081383..86211611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024998903.2 → XP_024854671.1  phosphatidate phosphatase LPIN1 isoform X6

    UniProtKB/TrEMBL
    A0A3Q1LKP8
    Related
    ENSBTAP00000060208.2, ENSBTAT00000083005.2
    Conserved Domains (3) summary
    pfam04571
    Location:50 → 156
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:680 → 905
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:518 → 608
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. XM_024998901.2 → XP_024854669.1  phosphatidate phosphatase LPIN1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LKP8
    Conserved Domains (3) summary
    pfam04571
    Location:50 → 156
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:715 → 940
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:553 → 643
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  3. XM_024998902.2 → XP_024854670.1  phosphatidate phosphatase LPIN1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1N3Z3
    Conserved Domains (3) summary
    pfam04571
    Location:37 → 143
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:702 → 927
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:540 → 630
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  4. XM_059891362.1 → XP_059747345.1  phosphatidate phosphatase LPIN1 isoform X3

  5. XM_059891363.1 → XP_059747346.1  phosphatidate phosphatase LPIN1 isoform X5

  6. XM_059891360.1 → XP_059747343.1  phosphatidate phosphatase LPIN1 isoform X1

  7. XM_024998907.2 → XP_024854675.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/TrEMBL
    A0A3Q1MY10
    Related
    ENSBTAP00000060798.2, ENSBTAT00000070606.2
    Conserved Domains (4) summary
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:631 → 856
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:469 → 559
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    cl26464
    Location:172 → 397
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version

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