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NFIX nuclear factor I X [ Bos taurus (domestic cattle) ]

Gene ID: 536348, updated on 10-Oct-2024

Summary

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Official Symbol
NFIXprovided by VGNC
Official Full Name
nuclear factor I Xprovided by VGNC
Primary source
VGNC:VGNC:32042
See related
BGD:BT15335; Ensembl:ENSBTAG00000018229
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NFIX in Genome Data Viewer
Location:
chromosome: 7
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (12478235..12576102, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene syntaxin 10 Neighboring gene nucleus accumbens associated 1 Neighboring gene tRNA methyltransferase 1 Neighboring gene LYL1 basic helix-loop-helix family member Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene DAN domain BMP antagonist family member 5 Neighboring gene GADD45G interacting protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel isoforms of the bovine Nuclear factor I/X (CCAAT-binding transcription factor) transcript products and their diverse expression profiles. Zhou Y, et al. Anim Genet, 2014 Aug. PMID 24889128
  2. Exploring polymorphisms and potential application roles of the bovine Nfix gene in breeding. Zhou Y, et al. Genome, 2012 Dec. PMID 23231603
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NFIX had highest expression in brain; medial expression in lung and muscle; and lower expression in spleen, kidney, liver and heart of both embryo and adult cattle. However, expression levels in adult tissues were significantly decreased.
    Title: Novel isoforms of the bovine Nuclear factor I/X (CCAAT-binding transcription factor) transcript products and their diverse expression profiles.
  2. Two sequence variants of the Nfix gene are significantly associated with growth traits at different ages.
    Title: Exploring polymorphisms and potential application roles of the bovine Nfix gene in breeding.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor 1 X-type

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    12478235..12576102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024994872.2 → XP_024850640.1  nuclear factor 1 X-type isoform X7

    UniProtKB/TrEMBL
    A0AAA9SD92, W8QDG6
    Related
    ENSBTAP00000084088.1, ENSBTAT00000099550.1
    Conserved Domains (3) summary
    pfam10524
    Location:9 → 46
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:213 → 502
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:68 → 170
    MH1; N-terminal Mad Homology 1 (MH1) domain

  2. XM_059888550.1 → XP_059744533.1  nuclear factor 1 X-type isoform X5

  3. XM_059888548.1 → XP_059744531.1  nuclear factor 1 X-type isoform X2

  4. XM_059888549.1 → XP_059744532.1  nuclear factor 1 X-type isoform X3

    Related
    ENSBTAP00000024262.7, ENSBTAT00000024262.7

  5. XM_059888547.1 → XP_059744530.1  nuclear factor 1 X-type isoform X1

  6. XM_002688747.7 → XP_002688793.3  nuclear factor 1 X-type isoform X8

    UniProtKB/TrEMBL
    A0AAA9SY16, W8QDG6
    Related
    ENSBTAP00000088969.1, ENSBTAT00000119638.1
    Conserved Domains (3) summary
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:205 → 494
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  7. XM_010806710.4 → XP_010805012.2  nuclear factor 1 X-type isoform X4

    UniProtKB/TrEMBL
    W8QDG6
    Conserved Domains (3) summary
    pfam00859
    Location:230 → 519
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:27 → 63
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:85 → 187
    MH1; N-terminal Mad Homology 1 (MH1) domain

  8. XM_005208640.5 → XP_005208697.1  nuclear factor 1 X-type isoform X6

    See identical proteins and their annotated locations for XP_005208697.1

    UniProtKB/TrEMBL
    A0A3Q1MIF8, W8QDG6
    Related
    ENSBTAP00000074090.2, ENSBTAT00000073398.2
    Conserved Domains (3) summary
    pfam10524
    Location:18 → 54
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:221 → 510
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:76 → 178
    MH1; N-terminal Mad Homology 1 (MH1) domain

  9. XM_059888551.1 → XP_059744534.1  nuclear factor 1 X-type isoform X9

    Related
    ENSBTAP00000067900.2, ENSBTAT00000069807.2

  10. XM_059888552.1 → XP_059744535.1  nuclear factor 1 X-type isoform X10

Nucleotide Protein Strain
Heading Accession and Version

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Research Materials