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NCK1 NCK adaptor protein 1 [ Bos taurus (domestic cattle) ]

Gene ID: 536154, updated on 4-Oct-2024

Summary

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Official Symbol
NCK1provided by VGNC
Official Full Name
NCK adaptor protein 1provided by VGNC
Primary source
VGNC:VGNC:52804
See related
BGD:BT27693; Ensembl:ENSBTAG00000018427
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NCK1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (132216618..132292949, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene interleukin 20 receptor subunit beta Neighboring gene uncharacterized LOC100847791 Neighboring gene solute carrier family 35 member G2 Neighboring gene translation machinery-associated protein 7-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC139414

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SH2/SH3 adapter protein NCK1; cytoplasmic protein NCK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076072.1 → NP_001069540.1  SH2/SH3 adapter protein NCK1

    See identical proteins and their annotated locations for NP_001069540.1

    Status: PROVISIONAL

    Source sequence(s)
    BC116109
    UniProtKB/TrEMBL
    F1MBQ7, Q1LZB2
    Related
    ENSBTAP00000024518.4, ENSBTAT00000024518.6
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cl17036
    Location:193 → 249
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    132216618..132292949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005201879.5 → XP_005201936.1  cytoplasmic protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_005201936.1

    UniProtKB/TrEMBL
    F1MBQ7, Q1LZB2
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cl17036
    Location:193 → 249
    SH3; Src Homology 3 domain superfamily

  2. XM_059885463.1 → XP_059741446.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    F1MBQ7, Q1LZB2

  3. XM_005201881.5 → XP_005201938.1  cytoplasmic protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_005201938.1

    UniProtKB/TrEMBL
    F1MBQ7, Q1LZB2
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cl17036
    Location:193 → 249
    SH3; Src Homology 3 domain superfamily

  4. XM_005201880.4 → XP_005201937.1  cytoplasmic protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_005201937.1

    UniProtKB/TrEMBL
    F1MBQ7, Q1LZB2
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cl17036
    Location:193 → 249
    SH3; Src Homology 3 domain superfamily

  5. XM_059885459.1 → XP_059741442.1  cytoplasmic protein NCK1 isoform X1

    UniProtKB/TrEMBL
    F1MBQ7, Q1LZB2

  6. XM_010801550.4 → XP_010799852.1  cytoplasmic protein NCK1 isoform X2

    See identical proteins and their annotated locations for XP_010799852.1

    UniProtKB/TrEMBL
    A0AAA9TSE2
    Related
    ENSBTAP00000100267.1, ENSBTAT00000131124.1
    Conserved Domains (3) summary
    cd10408
    Location:216 → 312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:44 → 98
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129 → 185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
Nucleotide Protein Strain
Heading Accession and Version

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