Dctn3 dynactin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dctn3provided by MGI
Official Full Name: dynactin 3provided by MGI
Primary source: MGI:MGI:1859251
See related: Ensembl:ENSMUSG00000028447 AllianceGenome:MGI:1859251
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p24
Summary: Acts upstream of or within microtubule-based process. Part of dynactin complex. Orthologous to human DCTN3 (dynactin subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 56.9), CNS E14 (RPKM 43.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 21.98 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41714798..41723213, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41714798..41723163, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule-based process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of dynactin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dynactin complex	IDA Inferred from Direct Assay more info	PubMed
part_of dynactin complex	ISO Inferred from Sequence Orthology more info
part_of dynactin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynactin subunit 3

Names: dynactin light chain (P24); dynactin light chain p24; p24 dynactin light chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159565.1 → NP_001153037.1 dynactin subunit 3 isoform B

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several in-frame segments in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform B), compared to isoform A.

Source sequence(s)

AK011840, AV493721, BY141790

Consensus CDS

CCDS51143.1

UniProtKB/TrEMBL

E9Q919

Related

ENSMUSP00000130988.2, ENSMUST00000171641.2

Conserved Domains (1) summary

pfam07426
Location:10 → 137

Dynactin_p22; Dynactin subunit p22
NM_016890.4 → NP_058586.3 dynactin subunit 3 isoform A

See identical proteins and their annotated locations for NP_058586.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).

Source sequence(s)

AK011840, BY141790

Consensus CDS

CCDS18069.1

UniProtKB/Swiss-Prot

Q9CR43, Q9D039, Q9Z0Y1

Related

ENSMUSP00000030158.5, ENSMUST00000030158.11

Conserved Domains (1) summary

pfam07426
Location:10 → 170

Dynactin_p22; Dynactin subunit p22

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

41714798..41723213 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164239.1 → XP_036020132.1 dynactin subunit 3 isoform X1

Conserved Domains (1) summary

pfam07426
Location:10 → 117

Dynactin_p22; Dynactin subunit p22