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dbo diablo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53556, updated on 2-Nov-2024

Summary

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Official Symbol
dboprovided by FlyBase
Official Full Name
diabloprovided by FlyBase
Primary source
FLYBASE:FBgn0040230
Locus tag
Dmel_CG6224
See related
AllianceGenome:FB:FBgn0040230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6224; Dbo; DIABLO; Dm.DBO; Dmel\CG6224; henji; Smac
Summary
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in negative regulation of synaptic assembly at neuromuscular junction and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; antennal anlage; ganglia; and head epidermis primordium. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See dbo in Genome Data Viewer
Location:
72A2-72A2; 3-43 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15826888..15832004)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15819988..15825104)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene CKII-alpha subunit interactor-1 Neighboring gene Decapping protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. Hawkins CJ, et al. Apoptosis, 2001 Oct. PMID 11483856
  2. The BACK domain in BTB-kelch proteins. Stogios PJ, et al. Trends Biochem Sci, 2004 Dec. PMID 15544948
  3. Drosophila veto puts a stop to cell survival. Holcik M. Trends Cell Biol, 2002 May. PMID 12062163
  4. Dbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response. Wang M, et al. PLoS Genet, 2016 Oct. PMID 27736876, Free PMC Article
  5. Drosophila decapping protein 2 modulates the formation of cortical F-actin for germ plasm assembly. Lee YM, et al. Dev Biol, 2020 May 1. PMID 32007453

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diablo
Names
CG6224-PA
CG6224-PB
DIABLO
dDiablo
dbo-PA
dbo-PB
henji

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15826888..15832004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080250.3 → NP_524989.2  diablo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524989.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NGX7, Q9VUU5
    Related
    FBpp0075260
    Conserved Domains (3) summary
    PHA03098
    Location:69 → 587
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:454 → 497
    Kelch; KELCH repeat [structural motif]
    cd18249
    Location:49 → 176
    BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)

  2. NM_001274963.1 → NP_001261892.1  diablo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261892.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFL3
    Conserved Domains (3) summary
    PHA03098
    Location:69 → 587
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:454 → 497
    Kelch; KELCH repeat [structural motif]
    cd18249
    Location:49 → 176
    BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFL3 M9PFL3
Q9VUU5.1 Q9VUU5

Gene LinkOut

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