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ACP2 acid phosphatase 2, lysosomal [ Bos taurus (domestic cattle) ]

Gene ID: 535407, updated on 10-Oct-2024

Summary

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Official Symbol
ACP2provided by VGNC
Official Full Name
acid phosphatase 2, lysosomalprovided by VGNC
Primary source
VGNC:VGNC:52601
See related
BGD:BT16438; Ensembl:ENSBTAG00000021002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Orthologs
human mouse all
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Genomic context

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See ACP2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (77114566..77125569, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene ADP ribosylation factor GTPase activating protein 2 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene damage specific DNA binding protein 2 Neighboring gene nuclear receptor subfamily 1 group H member 3 Neighboring gene MAP kinase activating death domain Neighboring gene microRNA mir-2318

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of efficient stop codon readthrough in four mammalian genes. Loughran G, et al. Nucleic Acids Res, 2014 Aug. PMID 25013167, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC142461

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lysosome organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lysosomal acid phosphatase
Names
LAP
NP_001069526.1
NP_001343973.1
XP_005216540.1
XP_005216541.1
XP_059730861.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076058.3 → NP_001069526.1  lysosomal acid phosphatase isoform 1 precursor

    See identical proteins and their annotated locations for NP_001069526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    BC120138, EH162752
    UniProtKB/Swiss-Prot
    Q0P5F0
    UniProtKB/TrEMBL
    A0AAA9T1H6
    Related
    ENSBTAP00000027968.4, ENSBTAT00000027968.5
    Conserved Domains (1) summary
    cd07061
    Location:32 → 330
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  2. NM_001357044.1 → NP_001343973.1  lysosomal acid phosphatase isoform 1x precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    BC120138, EH162752
    UniProtKB/TrEMBL
    A0AAA9T1H6
    Conserved Domains (1) summary
    cd07061
    Location:32 → 330
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    77114566..77125569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005216484.4 → XP_005216541.1  lysosomal acid phosphatase isoform X3

    UniProtKB/TrEMBL
    A0AAA9T1H6
    Conserved Domains (1) summary
    cl11399
    Location:32 → 329
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  2. XM_059874878.1 → XP_059730861.1  lysosomal acid phosphatase isoform X2

  3. XM_005216483.4 → XP_005216540.1  lysosomal acid phosphatase isoform X1

    UniProtKB/TrEMBL
    A0AAA9T1H6
    Conserved Domains (1) summary
    cd07061
    Location:32 → 339
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P5F0.1 GenPept UniProtKB/Swiss-Prot:Q0P5F0

Gene LinkOut

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