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GSN gelsolin [ Bos taurus (cattle) ]

Gene ID: 535077, updated on 6-Jun-2024

Summary

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Official Symbol
GSNprovided by VGNC
Official Full Name
gelsolinprovided by VGNC
Primary source
VGNC:VGNC:29680
See related
BGD:BT10049; Ensembl:ENSBTAG00000019915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See GSN in Genome Data Viewer
Location:
chromosome: 8
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (110672965..110733958)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101906836 Neighboring gene centriolin Neighboring gene RAB14, member RAS oncogene family Neighboring gene uncharacterized LOC101906903 Neighboring gene stomatin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Syntenic conservation between humans and cattle. I. Human chromosome 9. Threadgill DW, et al. Genomics, 1990 Sep. PMID 2081596
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC127421

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament severing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actin polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
gelsolin
Names
ADF
actin-depolymerizing factor
brevin
gelsolin (amyloidosis, Finnish type)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034627.1 → NP_001029799.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001029799.1

    Status: VALIDATED

    Source sequence(s)
    BC104560
    UniProtKB/Swiss-Prot
    Q3SX14
    UniProtKB/TrEMBL
    A0A3Q1MIW2
    Conserved Domains (6) summary
    cd11288
    Location:510 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135 → 224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388 → 488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  2. NM_001113284.1 → NP_001106755.1  gelsolin isoform a precursor

    See identical proteins and their annotated locations for NP_001106755.1

    Status: VALIDATED

    Source sequence(s)
    CK975948, DN522793, DT721010, DT812089, DV798542, DV922815
    UniProtKB/TrEMBL
    A0A3Q1MIW2
    Related
    ENSBTAP00000026534.6, ENSBTAT00000026534.7
    Conserved Domains (6) summary
    cd11288
    Location:560 → 648
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:185 → 274
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:58 → 170
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:665 → 763
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:294 → 394
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:438 → 538
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    110672965..110733958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059889166.1 → XP_059745149.1  gelsolin isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MIW2

  2. XM_059889165.1 → XP_059745148.1  gelsolin isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MIW2
    Related
    ENSBTAP00000071247.2, ENSBTAT00000076499.2

  3. XM_005210608.5 → XP_005210665.1  gelsolin isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MIW2
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  4. XM_024995842.2 → XP_024851610.1  gelsolin isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MIW2
    Conserved Domains (6) summary
    cd11288
    Location:521 → 609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146 → 235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19 → 131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626 → 724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255 → 355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399 → 499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  5. XM_024995841.2 → XP_024851609.1  gelsolin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MIW2, F1MJH1
    Related
    ENSBTAP00000051735.2, ENSBTAT00000053931.3
    Conserved Domains (6) summary
    cd11288
    Location:572 → 660
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:197 → 286
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:70 → 182
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:677 → 775
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:306 → 406
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:450 → 550
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  6. XM_005210607.4 → XP_005210664.2  gelsolin isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MIW2
    Related
    ENSBTAP00000071200.1, ENSBTAT00000076576.2
    Conserved Domains (6) summary
    cd11288
    Location:546 → 634
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:171 → 260
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:44 → 156
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:651 → 749
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:280 → 380
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:424 → 524
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SX14.1 GenPept UniProtKB/Swiss-Prot:Q3SX14

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