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ATP6V0A1 ATPase H+ transporting V0 subunit a1 [ Homo sapiens (human) ]

Gene ID: 535, updated on 3-Apr-2024

Summary

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Official Symbol
ATP6V0A1provided by HGNC
Official Full Name
ATPase H+ transporting V0 subunit a1provided by HGNC
Primary source
HGNC:HGNC:865
See related
Ensembl:ENSG00000033627 MIM:192130; AllianceGenome:HGNC:865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
a1; Stv1; VPP1; Vph1; ATP6N1; DEE104; NEDEBA; ATP6N1A
Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 46.5), kidney (RPKM 12.3) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17q21.2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42458878..42522579)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43316076..43379766)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40610896..40674597)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12200 Neighboring gene caveolae associated protein 1 Neighboring gene uncharacterized LOC102725238 Neighboring gene RNA, U7 small nuclear 97 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8530 Neighboring gene microRNA 548at Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40668625-40669124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8531 Neighboring gene microRNA 5010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8533 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40688565-40689302 Neighboring gene PTP4A2 pseudogene 1 Neighboring gene N-acetyl-alpha-glucosaminidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission. Yamazaki Y, et al. Elife, 2021 Dec 14. PMID 34904569, Free PMC Article
  2. Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. Hsin IL, et al. Br J Pharmacol, 2012 Nov. PMID 22708544, Free PMC Article
  3. Vacuolar H(+)-ATPase mutants transform cells and define a binding site for the papillomavirus E5 oncoprotein. Andresson T, et al. J Biol Chem, 1995 Mar 24. PMID 7896830
  4. ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice. Aoto K, et al. Nat Commun, 2021 Apr 8. PMID 33833240, Free PMC Article
  5. Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Brisson L, et al. Cancer Cell, 2016 Sep 12. PMID 27622334

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission.
    Title: V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission.
  2. ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.
    Title: ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.
  3. The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.
    Title: The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.
  4. Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. ATP6V0A1 plays an important role in mediating autophagosome-lysosome fusion.
    Title: Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.
  5. a series of events whereby ATP6V0A1 3'-UTR variant T+3246C functioned: ATP6V0A1 expression probably was affected through differential micro-RNA effects, altering vacuolar pH and consequently CHGA processing and exocytotic secretion.
    Title: A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk.
  6. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
  7. The mRNA levels of POLR2F, ATP6V0A1 and PRNP were evaluated by quantitative RT-PCR in 70 colorectal carcinomas and 17 normal tissue specimens and were correlated with clinicopathological parameters.
    Title: POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental and epileptic encephalopathy 104
MedGen: C5774183 OMIM: 619970 GeneReviews: Not available
not available
Neurodevelopmental disorder with epilepsy and brain atrophy
MedGen: C5774184 OMIM: 619971 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of ATPase, H+ transporting, lysosomal V0 subunit a1 (ATP6V0A1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781J1951

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endosomal lumen acidification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lysosomal lumen acidification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proton transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle lumen acidification IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar acidification TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in endosome membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lysosomal membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of proton-transporting V-type ATPase complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
V-type proton ATPase 116 kDa subunit a 1
Names
ATPase, H+ transporting, lysosomal V0 subunit a1
ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)
H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1
V-ATPase 116 kDa subunit a 1
V-ATPase 116 kDa subunit a1
V-ATPase subunit a1
V-type proton ATPase 116 kDa subunit a
V-type proton ATPase 116 kDa subunit a1
clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit
vacuolar adenosine triphosphatase subunit Ac116
vacuolar proton pump subunit 1
vacuolar proton translocating ATPase 116 kDa subunit A
vacuolar-type H(+)-ATPase 115 kDa subunit
NP_001123492.1
NP_001123493.1
NP_001365451.1
NP_001365452.1
NP_001365459.1
NP_001365460.1
NP_001365461.1
NP_001365462.1
NP_001365463.1
NP_001365464.1
NP_001365465.1
NP_001365466.1
NP_001365467.1
NP_001365468.1
NP_001365469.1
NP_001365470.1
NP_001365471.1
NP_001365472.1
NP_001365473.1
NP_001365474.1
NP_001365475.1
NP_001365476.1
NP_001365477.1
NP_001365478.1
NP_001365479.1
NP_001365480.1
NP_001365481.1
NP_001365483.1
NP_001365485.1
NP_001365486.1
NP_005168.2
XP_047292260.1
XP_047292261.1
XP_054172489.1
XP_054172490.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047037.1 RefSeqGene

    Range
    5035..68736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130020.3 → NP_001123492.1  V-type proton ATPase 116 kDa subunit a 1 isoform 2

    See identical proteins and their annotated locations for NP_001123492.1

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS45683.1
    UniProtKB/TrEMBL
    Q5CZH6
    Related
    ENSP00000264649.5, ENST00000264649.10
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 828
    V_ATPase_I; V-type ATPase 116kDa subunit family

  2. NM_001130021.3 → NP_001123493.1  V-type proton ATPase 116 kDa subunit a 1 isoform 1

    See identical proteins and their annotated locations for NP_001123493.1

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS45684.1
    UniProtKB/Swiss-Prot
    B7Z3B7, Q8N5G7, Q93050, Q9NSX0
    UniProtKB/TrEMBL
    Q53ET5
    Related
    ENSP00000342951.3, ENST00000343619.9
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 827
    V_ATPase_I; V-type ATPase 116kDa subunit family

  3. NM_001378522.1 → NP_001365451.1  V-type proton ATPase 116 kDa subunit a 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q5CZH6
    Related
    ENSP00000515529.1, ENST00000703892.1
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 834
    V_ATPase_I; V-type ATPase 116kDa subunit family

  4. NM_001378523.1 → NP_001365452.1  V-type proton ATPase 116 kDa subunit a 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q5CZH6
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 792
    V_ATPase_I; V-type ATPase 116kDa subunit family

  5. NM_001378530.1 → NP_001365459.1  V-type proton ATPase 116 kDa subunit a 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q53ET5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 893
    V_ATPase_I; V-type ATPase 116kDa subunit family

  6. NM_001378531.1 → NP_001365460.1  V-type proton ATPase 116 kDa subunit a 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q5CZH6
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 875
    V_ATPase_I; V-type ATPase 116kDa subunit family

  7. NM_001378532.1 → NP_001365461.1  V-type proton ATPase 116 kDa subunit a 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS92317.1
    UniProtKB/TrEMBL
    A0A994J3Z0, Q5CZH6
    Related
    ENSP00000515525.1, ENST00000703888.1
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 869
    V_ATPase_I; V-type ATPase 116kDa subunit family

  8. NM_001378533.1 → NP_001365462.1  V-type proton ATPase 116 kDa subunit a 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS92318.1
    UniProtKB/TrEMBL
    K7EN36, Q53ET5
    Related
    ENSP00000466767.2, ENST00000592324.2
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 868
    V_ATPase_I; V-type ATPase 116kDa subunit family

  9. NM_001378534.1 → NP_001365463.1  V-type proton ATPase 116 kDa subunit a 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q5CZH6
    Related
    ENSP00000515531.1, ENST00000703894.1
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 859
    V_ATPase_I; V-type ATPase 116kDa subunit family

  10. NM_001378535.1 → NP_001365464.1  V-type proton ATPase 116 kDa subunit a 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS92319.1
    UniProtKB/TrEMBL
    K7ENA1, Q53ET5
    Related
    ENSP00000466852.2, ENST00000588138.2
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 852
    V_ATPase_I; V-type ATPase 116kDa subunit family

  11. NM_001378536.1 → NP_001365465.1  V-type proton ATPase 116 kDa subunit a 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS92322.1
    UniProtKB/TrEMBL
    A0A994J3Z4, A0A994J473
    Related
    ENSP00000515530.1, ENST00000703893.1
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 791
    V_ATPase_I; V-type ATPase 116kDa subunit family

  12. NM_001378537.1 → NP_001365466.1  V-type proton ATPase 116 kDa subunit a 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q53ET5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 785
    V_ATPase_I; V-type ATPase 116kDa subunit family

  13. NM_001378538.1 → NP_001365467.1  V-type proton ATPase 116 kDa subunit a 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS92323.1
    UniProtKB/TrEMBL
    A0A994J473, B7Z2A9
    Related
    ENSP00000466878.1, ENST00000585525.5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 784
    V_ATPase_I; V-type ATPase 116kDa subunit family

  14. NM_001378539.1 → NP_001365468.1  V-type proton ATPase 116 kDa subunit a 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    A0A994J6N0
    Related
    ENSP00000515526.1, ENST00000703889.1
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 760
    V_ATPase_I; V-type ATPase 116kDa subunit family

  15. NM_001378540.1 → NP_001365469.1  V-type proton ATPase 116 kDa subunit a 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS92324.1
    UniProtKB/TrEMBL
    A0A994J473, B7Z641
    Related
    ENSP00000443991.1, ENST00000537728.5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 778
    V_ATPase_I; V-type ATPase 116kDa subunit family

  16. NM_001378541.1 → NP_001365470.1  V-type proton ATPase 116 kDa subunit a 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    A0A994J6N0
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 754
    V_ATPase_I; V-type ATPase 116kDa subunit family

  17. NM_001378542.1 → NP_001365471.1  V-type proton ATPase 116 kDa subunit a 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS92320.1
    UniProtKB/TrEMBL
    A0A994J4L9, K7ERA6
    Related
    ENSP00000468177.2, ENST00000586201.6
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 753
    V_ATPase_I; V-type ATPase 116kDa subunit family

  18. NM_001378543.1 → NP_001365472.1  V-type proton ATPase 116 kDa subunit a 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q5CZH6
    Conserved Domains (1) summary
    pfam01496
    Location:1 → 768
    V_ATPase_I; V-type ATPase 116kDa subunit family

  19. NM_001378544.1 → NP_001365473.1  V-type proton ATPase 116 kDa subunit a 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    A0A994J4L9
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 747
    V_ATPase_I; V-type ATPase 116kDa subunit family

  20. NM_001378545.1 → NP_001365474.1  V-type proton ATPase 116 kDa subunit a 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS92321.1
    UniProtKB/TrEMBL
    A0A994J3Z9, A0A994J473
    Related
    ENSP00000515535.1, ENST00000703897.1
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 757
    V_ATPase_I; V-type ATPase 116kDa subunit family

  21. NM_001378546.1 → NP_001365475.1  V-type proton ATPase 116 kDa subunit a 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q53ET5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 756
    V_ATPase_I; V-type ATPase 116kDa subunit family

  22. NM_001378547.1 → NP_001365476.1  V-type proton ATPase 116 kDa subunit a 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q53ET5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 750
    V_ATPase_I; V-type ATPase 116kDa subunit family

  23. NM_001378548.1 → NP_001365477.1  V-type proton ATPase 116 kDa subunit a 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q53ET5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 745
    V_ATPase_I; V-type ATPase 116kDa subunit family

  24. NM_001378549.1 → NP_001365478.1  V-type proton ATPase 116 kDa subunit a 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q53ET5
    Conserved Domains (1) summary
    pfam01496
    Location:1 → 767
    V_ATPase_I; V-type ATPase 116kDa subunit family

  25. NM_001378550.1 → NP_001365479.1  V-type proton ATPase 116 kDa subunit a 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    A0A994J473
    Conserved Domains (1) summary
    pfam01496
    Location:28 → 785
    V_ATPase_I; V-type ATPase 116kDa subunit family

  26. NM_001378551.1 → NP_001365480.1  V-type proton ATPase 116 kDa subunit a 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q53ET5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 862
    V_ATPase_I; V-type ATPase 116kDa subunit family

  27. NM_001378552.1 → NP_001365481.1  V-type proton ATPase 116 kDa subunit a 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    A0A994J4L9
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 788
    V_ATPase_I; V-type ATPase 116kDa subunit family

  28. NM_001378554.1 → NP_001365483.1  V-type proton ATPase 116 kDa subunit a 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    Q53ET5
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 751
    V_ATPase_I; V-type ATPase 116kDa subunit family

  29. NM_001378556.1 → NP_001365485.1  V-type proton ATPase 116 kDa subunit a 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    A0A994J4L9
    Conserved Domains (1) summary
    pfam01496
    Location:28 → 711
    V_ATPase_I; V-type ATPase 116kDa subunit family

  30. NM_001378557.1 → NP_001365486.1  V-type proton ATPase 116 kDa subunit a 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    UniProtKB/TrEMBL
    A0A994J4L9
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 711
    V_ATPase_I; V-type ATPase 116kDa subunit family

  31. NM_005177.5 → NP_005168.2  V-type proton ATPase 116 kDa subunit a 1 isoform 3

    See identical proteins and their annotated locations for NP_005168.2

    Status: REVIEWED

    Source sequence(s)
    AC067852, AC107993
    Consensus CDS
    CCDS11426.1
    UniProtKB/TrEMBL
    Q53ET5
    Related
    ENSP00000377415.2, ENST00000393829.6
    Conserved Domains (1) summary
    pfam01496
    Location:27 → 821
    V_ATPase_I; V-type ATPase 116kDa subunit family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    42458878..42522579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436305.1 → XP_047292261.1  V-type proton ATPase 116 kDa subunit a 1 isoform X2

  2. XM_047436304.1 → XP_047292260.1  V-type proton ATPase 116 kDa subunit a 1 isoform X1

RNA

  1. XR_007065303.1 RNA Sequence

  2. XR_007065304.1 RNA Sequence

  3. XR_007065306.1 RNA Sequence

  4. XR_007065305.1 RNA Sequence

  5. XR_007065307.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    43316076..43379766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316515.1 → XP_054172490.1  V-type proton ATPase 116 kDa subunit a 1 isoform X2

  2. XM_054316514.1 → XP_054172489.1  V-type proton ATPase 116 kDa subunit a 1 isoform X1

RNA

  1. XR_008484834.1 RNA Sequence

  2. XR_008484835.1 RNA Sequence

  3. XR_008484837.1 RNA Sequence

  4. XR_008484836.1 RNA Sequence

  5. XR_008484838.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93050.3 GenPept UniProtKB/Swiss-Prot:Q93050

Gene LinkOut

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