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DDR1 discoidin domain receptor tyrosine kinase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 534092, updated on 17-Aug-2024

Summary

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Official Symbol
DDR1provided by VGNC
Official Full Name
discoidin domain receptor tyrosine kinase 1provided by VGNC
Primary source
VGNC:VGNC:53966
See related
Ensembl:ENSBTAG00000010682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See DDR1 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (28172747..28186861, complement)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene valyl-tRNA synthetase 2, mitochondrial Neighboring gene general transcription factor IIH subunit 4 Neighboring gene uncharacterized LOC112443865 Neighboring gene uncharacterized LOC132343632

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables collagen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase collagen receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epithelial discoidin domain-containing receptor 1
Names
discoidin domain receptor family, member 1
NP_001069480.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076012.2 → NP_001069480.2  epithelial discoidin domain-containing receptor 1 precursor

    Status: VALIDATED

    Source sequence(s)
    BE665541, BI683201, BM107427, BT026168, CK848074, CN441168, DT885956, DV872957, DV875519, DY182348, DY199858
    UniProtKB/TrEMBL
    A0AAF6DMB3
    Related
    ENSBTAP00000043390.5, ENSBTAT00000046062.5
    Conserved Domains (4) summary
    cd05096
    Location:607 → 909
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00219
    Location:613 → 907
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:30 → 185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:33 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    28172747..28186861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials