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PLCB4 phospholipase C beta 4 [ Homo sapiens (human) ]

Gene ID: 5332, updated on 11-Apr-2024

Summary

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Official Symbol
PLCB4provided by HGNC
Official Full Name
phospholipase C beta 4provided by HGNC
Primary source
HGNC:HGNC:9059
See related
Ensembl:ENSG00000101333 MIM:600810; AllianceGenome:HGNC:9059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARCND2; PI-PLC; ARCND2A; ARCND2B
Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Expression
Broad expression in thyroid (RPKM 7.9), salivary gland (RPKM 5.4) and 19 other tissues See more
Orthologs
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Genomic context

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Location:
20p12.3-p12.2
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (9068678..9480808)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (9111633..9523716)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (9049325..9461455)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene phospholipase C beta 1 Neighboring gene Sharpr-MPRA regulatory region 2883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:8917332-8917836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:8917837-8918339 Neighboring gene RNA, U105B small nucleolar Neighboring gene uncharacterized LOC105372522 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:9031646-9032845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:9055836-9056336 Neighboring gene Sharpr-MPRA regulatory region 7247 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9160877-9161492 Neighboring gene MPRA-validated peak4143 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:9496172-9496756 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9499300-9500006 Neighboring gene uncharacterized LOC105372523 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:9553223-9553723 Neighboring gene LAMP5 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9557290-9557799 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene p21 (RAC1) activated kinase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants. Kanai SM, et al. Dis Model Mech, 2022 Apr 1. PMID 35284927, Free PMC Article
  2. Uveal melanoma-associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis. Phan HTN, et al. Sci Signal, 2021 Dec 14. PMID 34905385, Free PMC Article
  3. A familial PLCB4 mutation causing auriculocondylar syndrome 2 with variable severity. Nabil A, et al. Eur J Med Genet, 2020 Jun. PMID 32201334
  4. Targeted molecular investigation in patients within the clinical spectrum of Auriculocondylar syndrome. Romanelli Tavares VL, et al. Am J Med Genet A, 2017 Apr. PMID 28328130
  5. PLCB4 copy gain and PLCß4 overexpression in primary gastrointestinal stromal tumors: Integrative characterization of a lipid-catabolizing enzyme associated with worse disease-free survival. Li CF, et al. Oncotarget, 2017 Mar 21. PMID 28212550, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants.
    Title: Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants.
  2. The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.
    Title: The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.
  3. Uveal melanoma-associated mutations in PLCbeta4 are constitutively activating and promote melanocyte proliferation and tumorigenesis.
    Title: Uveal melanoma-associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis.
  4. Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.
    Title: Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.
  5. A familial PLCB4 mutation causing auriculocondylar syndrome 2 with variable severity.
    Title: A familial PLCB4 mutation causing auriculocondylar syndrome 2 with variable severity.
  6. Dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review)
    Title: Primary phospholipase C and brain disorders.
  7. Novel pathogenic variants in PLCB4 have been found in two of three index patients with typical Auriculocondylar syndrome.
    Title: Targeted molecular investigation in patients within the clinical spectrum of Auriculocondylar syndrome.
  8. Our observations of this case further delineate the phenotype of ACS associated with autosomal recessive PLCB4 loss-of-function mutations, underscoring gastrointestinal dysfunction and severe sleep-related breathing abnormalities as additional features when compared to patients with heterozygous mutations with a presumed dominant negative effect.
    Title: Respiratory and gastrointestinal dysfunctions associated with auriculo-condylar syndrome and a homozygous PLCB4 loss-of-function mutation.
  9. PLCB4 copy gain and PLCB4 overexpression is associated with gastrointestinal stromal tumors.
    Title: PLCB4 copy gain and PLCß4 overexpression in primary gastrointestinal stromal tumors: Integrative characterization of a lipid-catabolizing enzyme associated with worse disease-free survival.
  10. recurrent mutation in PLCB4 is associated with uveal melanoma.
    Title: Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Auriculocondylar syndrome 2
MedGen: C3553404 OMIM: 614669 GeneReviews: Not available
Compare labs
Auriculocondylar syndrome 2B
MedGen: C5830664 OMIM: 620458 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16169

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase C activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating endothelin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Names
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
PLC-beta-4
dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))
inositoltrisphosphohydrolase
monophosphatidylinositol phosphodiesterase
phosphoinositidase C
phosphoinositide phospholipase C-beta-4
triphosphoinositide phosphodiesterase
NP_000924.3
NP_001166117.1
NP_001364063.1
NP_001364064.1
NP_001364065.1
NP_001364071.1
NP_001364072.1
NP_877949.2
XP_005260781.1
XP_006723632.1
XP_011527556.1
XP_016883373.1
XP_024307666.1
XP_024307668.1
XP_047296157.1
XP_047296158.1
XP_047296159.1
XP_047296160.1
XP_047296161.1
XP_047296162.1
XP_054179488.1
XP_054179489.1
XP_054179490.1
XP_054179491.1
XP_054179492.1
XP_054179493.1
XP_054179494.1
XP_054179495.1
XP_054179496.1
XP_054179497.1
XP_054179498.1
XP_054179499.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032790.2 RefSeqGene

    Range
    5034..416755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000933.4 → NP_000924.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

    See identical proteins and their annotated locations for NP_000924.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the central coding region and includes an alternate exon in the 3' coding region that results in a frameshift, compared to variant 3. The complete exon combination of the 5' UTR for this variant has not been determined. The resulting isoform (a) lacks an internal segment and has a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS13104.1
    UniProtKB/TrEMBL
    A0A8I5KXD7
    Related
    ENSP00000508600.1, ENST00000686976.1
    Conserved Domains (6) summary
    PTZ00121
    Location:847 → 1194
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  2. NM_001172646.2 → NP_001166117.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform c.
    Source sequence(s)
    AK307837, AL117633, BC143868, DB270238, DN913865
    Consensus CDS
    CCDS54447.1
    UniProtKB/TrEMBL
    A0A8I5KQZ0
    Related
    ENSP00000508676.1, ENST00000685823.1
    Conserved Domains (6) summary
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl26511
    Location:851 → 1182
    Neuromodulin_N; Gap junction protein N-terminal region

  3. NM_001377134.2 → NP_001364063.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS13104.1
    UniProtKB/TrEMBL
    A0A8I5KXD7
    Related
    ENSP00000510118.1, ENST00000686871.1
    Conserved Domains (6) summary
    PTZ00121
    Location:847 → 1194
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  4. NM_001377135.1 → NP_001364064.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS13104.1
    UniProtKB/TrEMBL
    A0A8I5KXD7
    Related
    ENSP00000508595.1, ENST00000686313.1
    Conserved Domains (6) summary
    PTZ00121
    Location:847 → 1194
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  5. NM_001377136.1 → NP_001364065.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS13105.1
    UniProtKB/Swiss-Prot
    B7ZLK6, E2QRH8, Q15147, Q17R56, Q5JYS8, Q5JYS9, Q5JYT0, Q5JYT3, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2
    UniProtKB/TrEMBL
    A0A8I5KQZ0
    Related
    ENSP00000510302.1, ENST00000685859.1
    Conserved Domains (6) summary
    PTZ00121
    Location:839 → 1170
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

  6. NM_001377142.1 → NP_001364071.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS93005.1
    UniProtKB/TrEMBL
    A0A7P0MRI8, A0A8I5KS50
    Related
    ENSP00000367734.5, ENST00000378473.9
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  7. NM_001377143.1 → NP_001364072.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS93005.1
    UniProtKB/TrEMBL
    A0A7P0MRI8, A0A8I5KS50
    Related
    ENSP00000508726.1, ENST00000685568.1
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  8. NM_182797.3 → NP_877949.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    See identical proteins and their annotated locations for NP_877949.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 3. The complete exon combination of the 5' UTR for this variant has not been determined. The resulting isoform (b) lacks an internal segment, compared to isoform c.
    Source sequence(s)
    AL023805, AL031652, AL121898, AL121909
    Consensus CDS
    CCDS13105.1
    UniProtKB/Swiss-Prot
    B7ZLK6, E2QRH8, Q15147, Q17R56, Q5JYS8, Q5JYS9, Q5JYT0, Q5JYT3, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2
    UniProtKB/TrEMBL
    A0A8I5KQZ0
    Related
    ENSP00000508650.1, ENST00000689910.1
    Conserved Domains (6) summary
    PTZ00121
    Location:839 → 1170
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:914 → 955
    DUF1154; Protein of unknown function (DUF1154)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    9068678..9480808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451898.2 → XP_024307666.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A7P0MRI8, A0A8I5KS50
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  2. XM_005260724.3 → XP_005260781.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_005260781.1

    UniProtKB/TrEMBL
    A0A7P0MRI8, A0A8I5KS50
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  3. XM_006723569.3 → XP_006723632.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006723632.1

    UniProtKB/TrEMBL
    A0A7P0MRI8, A0A8I5KS50
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  4. XM_024451900.2 → XP_024307668.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A7P0MRI8, A0A8I5KS50
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  5. XM_047440201.1 → XP_047296157.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A7P0MRI8

  6. XM_047440202.1 → XP_047296158.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    Related
    ENSP00000509212.1, ENST00000492632.5

  7. XM_047440203.1 → XP_047296159.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A7P0MRI8

  8. XM_047440204.1 → XP_047296160.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

    Related
    ENSP00000508624.1, ENST00000690729.1

  9. XM_017027884.2 → XP_016883373.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KW09
    Conserved Domains (6) summary
    cd00275
    Location:601 → 717
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:199 → 567
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    pfam06631
    Location:813 → 854
    DUF1154; Protein of unknown function (DUF1154)
    cd16211
    Location:35 → 187
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    cl17171
    Location:1 → 30
    PH-like; Pleckstrin homology-like domain
    cl26511
    Location:746 → 1093
    Neuromodulin_N; Gap junction protein N-terminal region

  10. XM_011529254.3 → XP_011527556.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    UniProtKB/TrEMBL
    A0A8I5KW09
    Conserved Domains (6) summary
    cd00275
    Location:554 → 670
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:152 → 520
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:58 → 659
    PLN02228; Phosphoinositide phospholipase C
    pfam06631
    Location:766 → 806
    DUF1154; Protein of unknown function (DUF1154)
    pfam09279
    Location:61 → 152
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam09728
    Location:781 → 1018
    Taxilin; Myosin-like coiled-coil protein

  11. XM_047440205.1 → XP_047296161.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

    Related
    ENST00000482123.1

  12. XM_047440206.1 → XP_047296162.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    9111633..9523716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323515.1 → XP_054179490.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

  2. XM_054323517.1 → XP_054179492.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

  3. XM_054323516.1 → XP_054179491.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

  4. XM_054323518.1 → XP_054179493.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

  5. XM_054323513.1 → XP_054179488.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

  6. XM_054323514.1 → XP_054179489.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

  7. XM_054323519.1 → XP_054179494.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

  8. XM_054323521.1 → XP_054179496.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

  9. XM_054323520.1 → XP_054179495.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

  10. XM_054323522.1 → XP_054179497.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

  11. XM_054323523.1 → XP_054179498.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

  12. XM_054323524.1 → XP_054179499.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15147.3 GenPept UniProtKB/Swiss-Prot:Q15147

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