PKD2 polycystin 2, transient receptor potential cation channel [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PKD2provided by VGNC
Official Full Name: polycystin 2, transient receptor potential cation channelprovided by VGNC
Primary source: VGNC:VGNC:32935
See related: BGD:BT15888; Ensembl:ENSBTAG00000020031
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (36613501..36672178, complement)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables muscle alpha-actinin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables voltage-gated sodium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: polycystin-2

Names: polycystic kidney disease 2 membrane protein; polycystic kidney disease 2 protein homolog; transient receptor potential cation channel subfamily P member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001046312.1 → NP_001039777.1 polycystin-2

See identical proteins and their annotated locations for NP_001039777.1

Status: PROVISIONAL

Source sequence(s)

AJ871176

UniProtKB/Swiss-Prot

Q4GZT3

UniProtKB/TrEMBL

A0AAF6Z7P2

Related

ENSBTAP00000063046.2, ENSBTAT00000083983.2

Conserved Domains (2) summary

pfam08016
Location:269 → 689

PKD_channel; Polycystin cation channel

cl08302
Location:734 → 780

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...