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FLCN folliculin [ Bos taurus (domestic cattle) ]

Gene ID: 526652, updated on 4-Oct-2024

Summary

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Official Symbol
FLCNprovided by VGNC
Official Full Name
folliculinprovided by VGNC
Primary source
VGNC:VGNC:101448
See related
BGD:BT24728; Ensembl:ENSBTAG00000008010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See FLCN in Genome Data Viewer
Location:
chromosome: 19
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (34916050..34932171)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343053 Neighboring gene COP9 signalosome subunit 3 Neighboring gene phospholipase D family member 6 Neighboring gene myosin phosphatase Rho interacting protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC128946

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
folliculin
NP_001030440.1
XP_010814334.1
XP_010814335.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035363.1 → NP_001030440.1  folliculin

    See identical proteins and their annotated locations for NP_001030440.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107555
    UniProtKB/Swiss-Prot
    Q3B7L5
    UniProtKB/TrEMBL
    A0AAA9TY27
    Related
    ENSBTAP00000010532.5, ENSBTAT00000010532.7
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 264
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:349 → 563
    Folliculin_C; Folliculin C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34916050..34932171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010816033.4 → XP_010814335.1  folliculin isoform X2

    UniProtKB/TrEMBL
    A0AAA9TY27
    Conserved Domains (2) summary
    pfam11704
    Location:106 → 190
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:275 → 489
    Folliculin_C; Folliculin C-terminal domain

  2. XM_010816032.3 → XP_010814334.1  folliculin isoform X1

    UniProtKB/TrEMBL
    A0AAA9TY27
    Conserved Domains (2) summary
    pfam11704
    Location:32 → 190
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:275 → 489
    Folliculin_C; Folliculin C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B7L5.1 GenPept UniProtKB/Swiss-Prot:Q3B7L5

Gene LinkOut

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Molecular Biology Databases
Research Materials