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Wipi1 WD repeat domain, phosphoinositide interacting 1 [ Mus musculus (house mouse) ]

Gene ID: 52639, updated on 2-Nov-2024

Summary

Official Symbol
Wipi1provided by MGI
Official Full Name
WD repeat domain, phosphoinositide interacting 1provided by MGI
Primary source
MGI:MGI:1261864
See related
Ensembl:ENSMUSG00000041895 AllianceGenome:MGI:1261864
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D11Ertd498e; 4930533H01Rik
Summary
Predicted to enable several functions, including nuclear receptor binding activity; phosphatidylinositol phosphate binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of autophagosome assembly; and vesicle targeting, trans-Golgi to endosome. Located in phagophore assembly site. Is expressed in several structures, including central nervous system and retina. Orthologous to human WIPI1 (WD repeat domain, phosphoinositide interacting 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 28.8), subcutaneous fat pad adult (RPKM 20.4) and 28 other tissues See more
Orthologs
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Genomic context

See Wipi1 in Genome Data Viewer
Location:
11 E1; 11 72.18 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109464347..109502215, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109573521..109611389, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45916 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E5294 Neighboring gene STARR-positive B cell enhancer ABC_E7088 Neighboring gene STARR-positive B cell enhancer ABC_E1846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109357315-109357468 Neighboring gene arylsulfatase G Neighboring gene predicted gene, 22378 Neighboring gene STARR-positive B cell enhancer ABC_E7089 Neighboring gene predicted gene, 39442 Neighboring gene STARR-positive B cell enhancer ABC_E259 Neighboring gene STARR-positive B cell enhancer ABC_E11498 Neighboring gene predicted gene 11685 Neighboring gene STARR-seq mESC enhancer starr_31024 Neighboring gene STARR-positive B cell enhancer ABC_E7090 Neighboring gene protein kinase, cAMP dependent regulatory, type I, alpha Neighboring gene predicted gene, 39443

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC36416

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear androgen receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein lipidation involved in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle targeting, trans-Golgi to endosome IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle targeting, trans-Golgi to endosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagophore assembly site membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WD repeat domain phosphoinositide-interacting protein 1
Names
WD40 repeat protein Interacting with phosphoInositides of 49kDa
WD40 repeat protein interacting with phosphoinositides of 49 kDa
WIPI 49 kDa
WIPI-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145940.2NP_666052.1  WD repeat domain phosphoinositide-interacting protein 1

    See identical proteins and their annotated locations for NP_666052.1

    Status: PROVISIONAL

    Source sequence(s)
    AL645791, AL732387
    Consensus CDS
    CCDS25582.1
    UniProtKB/Swiss-Prot
    Q8BGE1, Q8R1A9, Q8R1C7, Q8R3E3
    Related
    ENSMUSP00000099349.4, ENSMUST00000103060.10
    Conserved Domains (3) summary
    COG2319
    Location:100265
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:144184
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:88262
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    109464347..109502215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)