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SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 524683, updated on 12-Oct-2024

Summary

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Official Symbol
SAMHD1provided by VGNC
Official Full Name
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1provided by VGNC
Primary source
VGNC:VGNC:34277
See related
BGD:BT20536; Ensembl:ENSBTAG00000022007
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SAMHD1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (65915450..65982707, complement)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene DSN1 component of MIS12 kinetochore complex Neighboring gene suppressor of glucose, autophagy associated 1 Neighboring gene uncharacterized LOC132346957 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene TBC/LysM-associated domain containing 2 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1-like Neighboring gene uncharacterized LOC533073 Neighboring gene glucosamine-6-phosphate isomerase 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction. Wang C, et al. Virol Sin, 2021 Oct. PMID 33751400, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction.
    Title: Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC142499

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables dGTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dGTP catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Names
SAM domain and HD domain-containing protein 1
dNTPase
NP_001069329.1
XP_024856386.1
XP_024856388.1
XP_024856389.1
XP_059748601.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075861.2 → NP_001069329.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1

    See identical proteins and their annotated locations for NP_001069329.1

    Status: PROVISIONAL

    Source sequence(s)
    BC120271
    UniProtKB/Swiss-Prot
    Q0VCA5
    UniProtKB/TrEMBL
    A0AAA9TMF7
    Related
    ENSBTAP00000041236.3, ENSBTAT00000043682.3
    Conserved Domains (3) summary
    COG1078
    Location:103 → 517
    YdhJ; HD superfamily phosphohydrolase [General function prediction only]
    cd00077
    Location:150 → 324
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    cl15755
    Location:41 → 100
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    65915450..65982707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000618.2 → XP_024856386.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9TMF7
    Related
    ENSBTAP00000099566.1, ENSBTAT00000126640.1
    Conserved Domains (2) summary
    cl15755
    Location:41 → 100
    SAM_superfamily; SAM (Sterile alpha motif )
    cl26231
    Location:103 → 517
    YdhJ; HD superfamily phosphohydrolase [General function prediction only]

  2. XM_025000620.2 → XP_024856388.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2

    UniProtKB/TrEMBL
    A0AAA9TMF7
    Conserved Domains (2) summary
    cl15755
    Location:41 → 100
    SAM_superfamily; SAM (Sterile alpha motif )
    cl26231
    Location:103 → 517
    YdhJ; HD superfamily phosphohydrolase [General function prediction only]

  3. XM_059892618.1 → XP_059748601.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X4

    Related
    ENSBTAP00000075738.1, ENSBTAT00000103938.1

  4. XM_025000621.2 → XP_024856389.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X3

    UniProtKB/TrEMBL
    A0AAA9RSS3
    Conserved Domains (2) summary
    cl15755
    Location:41 → 100
    SAM_superfamily; SAM (Sterile alpha motif )
    cl26231
    Location:103 → 472
    YdhJ; HD superfamily phosphohydrolase [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VCA5.1 GenPept UniProtKB/Swiss-Prot:Q0VCA5

Gene LinkOut

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