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PARD6A par-6 family cell polarity regulator alpha [ Bos taurus (domestic cattle) ]

Gene ID: 524653, updated on 4-Oct-2024

Summary

Official Symbol
PARD6Aprovided by VGNC
Official Full Name
par-6 family cell polarity regulator alphaprovided by VGNC
Primary source
VGNC:VGNC:32583
See related
BGD:BT27156; Ensembl:ENSBTAG00000023734
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
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Genomic context

See PARD6A in Genome Data Viewer
Location:
chromosome: 18
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (35214465..35216508)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342823 Neighboring gene CCCTC-binding factor Neighboring gene capping protein regulator and myosin 1 linker 2 Neighboring gene chromosome 18 C16orf86 homolog Neighboring gene ACD shelterin complex subunit and telomerase recruitment factor Neighboring gene enkurin domain containing 1 Neighboring gene glucose-fructose oxidoreductase domain containing 2 Neighboring gene uncharacterized LOC132342824

Genomic regions, transcripts, and products

Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Pathways from PubChem

General gene information

Clone Names

  • MGC137799

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein kinase C binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in centrosome cycle IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in establishment or maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in regulation of cellular localization IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
partitioning defective 6 homolog alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046274.1NP_001039739.1  partitioning defective 6 homolog alpha

    See identical proteins and their annotated locations for NP_001039739.1

    Status: PROVISIONAL

    Source sequence(s)
    BC113337
    UniProtKB/TrEMBL
    Q2HJ32
    Conserved Domains (2) summary
    cd06403
    Location:1695
    PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
    cd00992
    Location:156247
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    35214465..35216508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024978302.2XP_024834070.1  partitioning defective 6 homolog alpha isoform X1

    UniProtKB/TrEMBL
    F6RHP0
    Related
    ENSBTAP00000032435.6, ENSBTAT00000032504.6
    Conserved Domains (2) summary
    cd06403
    Location:1695
    PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
    cd00992
    Location:155246
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...