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GRK6 G protein-coupled receptor kinase 6 [ Bos taurus (domestic cattle) ]

Gene ID: 521413, updated on 10-Oct-2024

Summary

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Official Symbol
GRK6provided by VGNC
Official Full Name
G protein-coupled receptor kinase 6provided by VGNC
Primary source
VGNC:VGNC:29657
See related
Ensembl:ENSBTAG00000043994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See GRK6 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (38925916..38940650)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene profilin 3 Neighboring gene coagulation factor XII Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC112447400 Neighboring gene proline rich 7, synaptic

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. Jann OC, et al. BMC Genomics, 2006 Nov 6. PMID 17087818, Free PMC Article
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
G protein-coupled receptor kinase 6
NP_001178459.1
NP_001192319.1
XP_024850019.1
XP_059744169.1
XP_059744170.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191530.1 → NP_001178459.1  G protein-coupled receptor kinase 6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BF605412, CO873051, CO876214, DY071905, DY094222, DY121035, DY158204, EV633678, NKLS02000007
    UniProtKB/TrEMBL
    A0AAA9SIA4, E1BP29
    Conserved Domains (2) summary
    cd05630
    Location:185 → 469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35 → 179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_001205390.1 → NP_001192319.1  G protein-coupled receptor kinase 6 isoform 2

    See identical proteins and their annotated locations for NP_001192319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate short exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BE664831, BF605412, CO873051, CO876214, DY071905, DY158204, EV633678, NKLS02000007
    UniProtKB/TrEMBL
    A0AAA9SIA4
    Related
    ENSBTAP00000053464.3, ENSBTAT00000061163.4
    Conserved Domains (2) summary
    cd05630
    Location:185 → 469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35 → 179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    38925916..38940650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059888187.1 → XP_059744170.1  G protein-coupled receptor kinase 6 isoform X3

    UniProtKB/TrEMBL
    E1BP29

  2. XM_024994251.2 → XP_024850019.1  G protein-coupled receptor kinase 6 isoform X1

    UniProtKB/TrEMBL
    A0AAA9SIA4
    Related
    ENSBTAP00000083391.1, ENSBTAT00000091746.1
    Conserved Domains (2) summary
    cd05630
    Location:185 → 469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35 → 179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. XM_059888186.1 → XP_059744169.1  G protein-coupled receptor kinase 6 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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