NAMPT nicotinamide phosphoribosyltransferase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: NAMPTprovided by VGNC
Official Full Name: nicotinamide phosphoribosyltransferaseprovided by VGNC
Primary source: VGNC:VGNC:31875
See related: BGD:BT23755; Ensembl:ENSBTAG00000015509
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: PBEF; PBEF1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (47321227..47361906, complement)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
Title: Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis.
the presence of 35bp-insertion in visfatin gene may influence the birth weight and bodyweight in 6-month-old cows.
Title: [Novel 35-bp insertion in visfatin gene in Chinese cattle].
These results indicate that mammary epithelial cells express the visfatin protein and secrete them into the milk.
Title: Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables nicotinamide phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nicotinamide phosphoribosyltransferase

Names: pre-B-cell colony enhancing factor 1; visfatin

NP_001231070.1

EC 2.4.2.12

XP_010802469.1

EC 2.4.2.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244141.1 → NP_001231070.1 nicotinamide phosphoribosyltransferase

See identical proteins and their annotated locations for NP_001231070.1

Status: PROVISIONAL

Source sequence(s)

BC151730, CB431562, CB460095, DR113822, EE900191, EE900192, FE004250

UniProtKB/TrEMBL

A0A3Q1M241, A0AAA9RTK3

Related

ENSBTAP00000064059.1, ENSBTAT00000083136.1

Conserved Domains (1) summary

cd01569
Location:12 → 428

PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

Range

47321227..47361906 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010804167.3 → XP_010802469.1 nicotinamide phosphoribosyltransferase isoform X1

UniProtKB/TrEMBL

A0AAA9RTK3, A0AAA9SXQ5

Related

ENSBTAP00000089013.1, ENSBTAT00000123233.1

Conserved Domains (2) summary

PRK09198
Location:10 → 434

PRK09198; putative nicotinate phosphoribosyltransferase; Provisional

cl21457
Location:12 → 381

TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...