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PFDN2 prefoldin subunit 2 [ Homo sapiens (human) ]

Gene ID: 5202, updated on 5-Mar-2024

Summary

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Official Symbol
PFDN2provided by HGNC
Official Full Name
prefoldin subunit 2provided by HGNC
Primary source
HGNC:HGNC:8867
See related
Ensembl:ENSG00000143256 MIM:613466; AllianceGenome:HGNC:8867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFD2
Summary
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 33.7), brain (RPKM 30.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161100561..161118037, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160238042..160255506, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161070351..161087827, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nectin cell adhesion molecule 4 Neighboring gene NECTIN4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1467 Neighboring gene kelch domain containing 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161087283-161088263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161093620-161094120 Neighboring gene nitrilase 1 Neighboring gene death effector domain containing Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161101327-161102150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1977 Neighboring gene linc-UFC1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of prefoldin amplification (1q23.3-q24.1) in bladder cancer using comparative genomic hybridization (CGH) arrays of urinary DNA. López V, et al. J Transl Med, 2013 Aug 1. PMID 23914742, Free PMC Article
  2. Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation. Tashiro E, et al. J Biol Chem, 2013 Jul 5. PMID 23720755, Free PMC Article
  3. Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization. Tsao ML, et al. Biochem Biophys Res Commun, 2006 Sep 15. PMID 16876117
  4. A chaperone with a hydrophilic surface. Cowan NJ, et al. Nat Struct Biol, 1999 Nov. PMID 10542082
  5. Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins. Hansen WJ, et al. J Cell Biol, 1999 Apr 19. PMID 10209023, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. prefoldin is amplified at 1q23.3-q24.1 in bladder cancer
    Title: Identification of prefoldin amplification (1q23.3-q24.1) in bladder cancer using comparative genomic hybridization (CGH) arrays of urinary DNA.
  2. knockdown of PFD2 and PFD5 disrupted prefoldin formation in HTT-expressing cells, resulting in accumulation of aggregates of a pathogenic form of HTT and in induction of cell death.
    Title: Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation.
  3. Is part of an RNA polymerase II-associated complex with possible chaperone activity.
    Title: High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein folding chaperone IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of amyloid fibril formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein stabilization NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of prefoldin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of prefoldin complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of protein folding chaperone complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
prefoldin subunit 2
Names
prefoldin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012394.4 → NP_036526.2  prefoldin subunit 2

    See identical proteins and their annotated locations for NP_036526.2

    Status: REVIEWED

    Source sequence(s)
    AF165883, BC012464
    Consensus CDS
    CCDS1217.1
    UniProtKB/Swiss-Prot
    Q9P0P7, Q9UHV9, Q9UN05
    UniProtKB/TrEMBL
    B1AQP2
    Related
    ENSP00000356989.3, ENST00000368010.4
    Conserved Domains (1) summary
    pfam01920
    Location:27 → 128
    Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161100561..161118037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509624.4 → XP_011507926.1  prefoldin subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011507926.1

    UniProtKB/Swiss-Prot
    Q9UHV9
    Conserved Domains (1) summary
    pfam01920
    Location:1 → 80
    Prefoldin_2; Prefoldin subunit

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160238042..160255506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337022.1 → XP_054192997.1  prefoldin subunit 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UHV9.1 GenPept UniProtKB/Swiss-Prot:Q9UHV9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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